PMID- 25800148
OWN - NLM
STAT- MEDLINE
DCOM- 20160105
LR  - 20150420
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 56
DP  - 2015 Jun
TI  - BDNF and cortisol levels in children with or without post-traumatic stress 
      disorder after sustaining sexual abuse.
PG  - 45-51
LID - S0306-4530(15)00078-5 [pii]
LID - 10.1016/j.psyneuen.2015.02.017 [doi]
AB  - OBJECTIVE: There are studies reporting that cortisol and brain-derived 
      neurotropic factor (BDNF) play a role in the pathophysiology of post-traumatic 
      stress disorder (PTSD). However, up-to-date no study evaluated the relationship 
      between PTSD and the levels of cortisol and BDNF in children and adolescents who 
      have sustained trauma. The aim of this study was to investigate whether BDNF, 
      cortisol and adrenocorticotropine (ACTH) levels differ between individuals who 
      developed PTSD or not following a sexual trauma. METHOD: The study included 55 
      children aged between 6 and 17 years who sustained sexual assault (M/F: 13/42). 
      The patients were divided into two groups, with or without PTSD based on the 
      results of a structured psychiatric interview (K-SADS-PL and CAPS-CA). Of the 
      participants, 49% (n=27) were diagnosed with PTSD. Cortisol, ACTH, and BDNF 
      levels were evaluated using the ELISA method. RESULTS: There were no significant 
      differences between patients with or without PTSD in terms of cortisol, ACTH, 
      BDNF levels. There were no correlations between CAPS-CA scores and cortisol, 
      ACTH, and BDNF levels in patients with or without PTSD. In patients with PTSD, 
      decreased cortisol levels were found with increasing time after trauma, and no 
      significant correlation was found with the cortisol levels in patients without 
      PTSD. CONCLUSION: Although no significant association was found between 
      biochemical parameters and the presence or severity of PTSD; decreasing cortisol 
      levels with increasing time after trauma in patients with PTSD suggest that 
      cortisol might have played a role in the pathophysiology of this disorder.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Simsek, Seref
AU  - Simsek S
AD  - Dicle University, Medical School, Department of Child Psychiatry, Diyarbakir, 
      Turkey. Electronic address: drserefsimsek@gmail.com.
FAU - Uysal, Cem
AU  - Uysal C
AD  - Dicle University, Medical School, Department of Forensic Medicine, Diyarbakir, 
      Turkey. Electronic address: drcemuysal@gmail.com.
FAU - Kaplan, Ibrahim
AU  - Kaplan I
AD  - Dicle University, Medical School, Department of Biochemistry, Diyarbakir, Turkey. 
      Electronic address: dribrahimkaplan@hotmail.com.
FAU - Yuksel, Tugba
AU  - Yuksel T
AD  - Dicle University, Medical School, Department of Child Psychiatry, Diyarbakir, 
      Turkey. Electronic address: tyuksel44@yahoo.com.
FAU - Aktas, Huseyin
AU  - Aktas H
AD  - Dicle University, Medical School, Department of Child Psychiatry, Diyarbakir, 
      Turkey. Electronic address: huseyinaktas04@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20150310
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adolescent
MH  - Adrenocorticotropic Hormone/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Child Abuse, Sexual/*psychology
MH  - Depression/psychology
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Interview, Psychological
MH  - Male
MH  - Mood Disorders/epidemiology/psychology
MH  - Schizophrenia/epidemiology
MH  - Schizophrenic Psychology
MH  - Socioeconomic Factors
MH  - Stress Disorders, Post-Traumatic/*blood/etiology/*psychology
OTO - NOTNLM
OT  - BDNF
OT  - Cortisol
OT  - HPA axis
OT  - PTSD
OT  - Sexual abuse
OT  - Trauma
EDAT- 2015/03/25 06:00
MHDA- 2016/01/06 06:00
CRDT- 2015/03/25 06:00
PHST- 2014/12/01 00:00 [received]
PHST- 2015/02/12 00:00 [revised]
PHST- 2015/02/23 00:00 [accepted]
PHST- 2015/03/25 06:00 [entrez]
PHST- 2015/03/25 06:00 [pubmed]
PHST- 2016/01/06 06:00 [medline]
AID - S0306-4530(15)00078-5 [pii]
AID - 10.1016/j.psyneuen.2015.02.017 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2015 Jun;56:45-51. doi: 10.1016/j.psyneuen.2015.02.017. 
      Epub 2015 Mar 10.