PMID- 25800506
OWN - NLM
STAT- MEDLINE
DCOM- 20160106
LR  - 20150420
IS  - 1973-8102 (Electronic)
IS  - 0010-9452 (Linking)
VI  - 66
DP  - 2015 May
TI  - Three distinct fiber pathways of the bed nucleus of the stria terminalis to the 
      amygdala and prefrontal cortex.
PG  - 60-8
LID - S0010-9452(15)00064-7 [pii]
LID - 10.1016/j.cortex.2015.02.007 [doi]
AB  - The bed nucleus of the stria terminalis (BNST) is an important relay for multiple 
      cortical and subcortical regions involved in processing anxiety as well as 
      neuroendocrine and autonomic responses to stress, and it is thought to play a 
      role in the dysregulation of these functions as well as in addictive behavior. 
      While its architecture and connection profile have been thoroughly examined in 
      animals, studies in humans have been limited to post-mortem histological 
      descriptions of the BNST itself, not accounting for the distribution of its 
      various connections. In the current study, we used diffusion-weighted magnetic 
      resonance imaging (DW-MRI) to investigate the courses of fiber tracks connected 
      to the BNST in humans. We restricted our seed region for probabilistic fiber 
      tracking to the dorsal part of the BNST, as the ventral BNST is not 
      distinguishable from the surrounding grey matter structures using magnetic 
      resonance imaging. Our results show two distinct pathways of the BNST to the 
      amygdala via the stria terminalis and the ansa peduncularis, as well as 
      connections to the hypothalamus. Finally, we distinguished a route to the 
      orbitofrontal cortex (OFC) running through the head of the caudate nucleus (CN) 
      and the nucleus accumbens (NAcc). Pathways to brainstem regions were found to 
      show a considerable inter-individual variability and thus no common pathway could 
      be identified across participants. In summary, our findings reveal a complex 
      network of brain structures involved in behavioral and neuroendocrine regulation, 
      with the BNST in a central position.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Kruger, Oliver
AU  - Kruger O
AD  - Department of Biomedical Magnetic Resonance, University of Tubingen, Germany. 
      Electronic address: oliver.krueger@student.uni-tuebingen.de.
FAU - Shiozawa, Thomas
AU  - Shiozawa T
AD  - Department of Anatomy, University of Tubingen, Germany.
FAU - Kreifelts, Benjamin
AU  - Kreifelts B
AD  - Clinic for Psychiatry and Psychotherapy, University of Tubingen, Germany.
FAU - Scheffler, Klaus
AU  - Scheffler K
AD  - Department of Biomedical Magnetic Resonance, University of Tubingen, Germany; 
      Max-Planck-Institute for Biological Cybernetics, University of Tubingen, Germany.
FAU - Ethofer, Thomas
AU  - Ethofer T
AD  - Department of Biomedical Magnetic Resonance, University of Tubingen, Germany; 
      Clinic for Psychiatry and Psychotherapy, University of Tubingen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20150302
PL  - Italy
TA  - Cortex
JT  - Cortex; a journal devoted to the study of the nervous system and behavior
JID - 0100725
SB  - IM
MH  - Adult
MH  - Amygdala/*anatomy & histology
MH  - Brain/anatomy & histology
MH  - Brain Stem/anatomy & histology
MH  - Caudate Nucleus/anatomy & histology
MH  - Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Neural Pathways/anatomy & histology
MH  - Nucleus Accumbens/anatomy & histology
MH  - Prefrontal Cortex/*anatomy & histology
MH  - Septal Nuclei/*anatomy & histology
MH  - Young Adult
OTO - NOTNLM
OT  - Anxiety
OT  - BNST
OT  - DTI
OT  - OFC
OT  - mPFC
EDAT- 2015/03/25 06:00
MHDA- 2016/01/07 06:00
CRDT- 2015/03/25 06:00
PHST- 2014/10/22 00:00 [received]
PHST- 2015/01/29 00:00 [revised]
PHST- 2015/02/18 00:00 [accepted]
PHST- 2015/03/25 06:00 [entrez]
PHST- 2015/03/25 06:00 [pubmed]
PHST- 2016/01/07 06:00 [medline]
AID - S0010-9452(15)00064-7 [pii]
AID - 10.1016/j.cortex.2015.02.007 [doi]
PST - ppublish
SO  - Cortex. 2015 May;66:60-8. doi: 10.1016/j.cortex.2015.02.007. Epub 2015 Mar 2.