PMID- 25800856
OWN - NLM
STAT- MEDLINE
DCOM- 20160817
LR  - 20220317
IS  - 1651-226X (Electronic)
IS  - 0284-186X (Linking)
VI  - 54
IP  - 10
DP  - 2015 Nov
TI  - Monte-Carlo dosimetry for intraoperative radiotherapy using a low energy x-ray 
      source.
PG  - 1788-95
LID - 10.3109/0284186X.2015.1016623 [doi]
AB  - Intraoperative radiotherapy (IORT) is continuously gaining ground in cancer 
      treatment. However, there is currently no planning system associated with these 
      devices, which precludes patient-specific dose delivery optimization. The 
      objective of this study was the development and validation of a Monte Carlo 
      simulation (MCS)-based dosimetry platform using the Intrabeam system. METHODS: 
      After surgical resection of the tumor this system delivers a single dose fraction 
      at the surface of an applicator irradiating the tumor bed through a 50 kV x-ray 
      beam. The GATE MCS platform was used in this study combining the phase space 
      obtained by modeling the x-ray source and the detailed modeling of the additional 
      parts of the Intrabeam system. The model was validated by comparing simulated 
      versus experimental measurements of depth dose curves (DDC) and isotropy. A 
      clinical validation study was also carried out using patient computed tomography 
      images. RESULTS: The mean deviation between measured and simulated DDC was 2.9% +/- 
      4.4% and 5.9% +/- 5.7% for the bare needle and the use of applicators, 
      respectively. A good agreement with experimental measurements was also found in 
      terms of dose isotropy with a maximum difference of 2.04% for the 40 mm diameter 
      applicator. A patient study revealed a mean absolute deviation of 0.06 Gy between 
      simulated and thermoluminescent dosimeters (TLD) measured skin doses. CONCLUSION: 
      This study shows the potential of using the GATE MCS platform to model 
      three-dimensional dose distributions of the Intrabeam system for use in IORT.
FAU - Bouzid, Dounia
AU  - Bouzid D
AD  - a Inserm UMR1101 , LaTIM, Brest , France.
AD  - b Department of Radiotherapy , CHRU Brest , France.
FAU - Bert, Julien
AU  - Bert J
AD  - a Inserm UMR1101 , LaTIM, Brest , France.
FAU - Dupre, Pierre-Francois
AU  - Dupre PF
AD  - c Department of Gynecology and Surgery , CHRU Brest , France.
FAU - Benhalouche, Saadia
AU  - Benhalouche S
AD  - a Inserm UMR1101 , LaTIM, Brest , France.
FAU - Pradier, Olivier
AU  - Pradier O
AD  - a Inserm UMR1101 , LaTIM, Brest , France.
AD  - b Department of Radiotherapy , CHRU Brest , France.
FAU - Boussion, Nicolas
AU  - Boussion N
AD  - a Inserm UMR1101 , LaTIM, Brest , France.
AD  - b Department of Radiotherapy , CHRU Brest , France.
FAU - Visvikis, Dimitris
AU  - Visvikis D
AD  - a Inserm UMR1101 , LaTIM, Brest , France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20150324
PL  - Sweden
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
SB  - IM
MH  - Breast Neoplasms/diagnostic imaging/*radiotherapy/*surgery
MH  - Computer Simulation
MH  - Female
MH  - Humans
MH  - Intraoperative Care
MH  - Mastectomy, Segmental
MH  - *Models, Theoretical
MH  - Monte Carlo Method
MH  - Phantoms, Imaging
MH  - Radiotherapy/instrumentation
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/instrumentation/*methods
MH  - Radiotherapy, Computer-Assisted
MH  - Skin
MH  - Thermoluminescent Dosimetry
MH  - Tomography, X-Ray Computed
EDAT- 2015/03/25 06:00
MHDA- 2016/08/18 06:00
CRDT- 2015/03/25 06:00
PHST- 2015/03/25 06:00 [entrez]
PHST- 2015/03/25 06:00 [pubmed]
PHST- 2016/08/18 06:00 [medline]
AID - 10.3109/0284186X.2015.1016623 [doi]
PST - ppublish
SO  - Acta Oncol. 2015 Nov;54(10):1788-95. doi: 10.3109/0284186X.2015.1016623. Epub 
      2015 Mar 24.