PMID- 25801118
OWN - NLM
STAT- MEDLINE
DCOM- 20160927
LR  - 20220311
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1628
IP  - Pt A
DP  - 2015 Dec 2
TI  - Corticostriatal BDNF and alcohol addiction.
PG  - 60-7
LID - S0006-8993(15)00221-8 [pii]
LID - 10.1016/j.brainres.2015.03.025 [doi]
AB  - Growth factors, long studied for their involvement in neuronal development and 
      plasticity, also regulate responses to drugs of abuse, including alcohol. This 
      review details the intricate interaction between the Brain-Derived Neurotrophic 
      Factor (BDNF) and alcohol, and provides evidence to suggest that corticostriatal 
      BDNF signaling acts to keep alcohol drinking in moderation. Specifically, we 
      describe studies in rodent models suggesting that moderate consumption of alcohol 
      increases BDNF levels in the dorsal striatum, which in turn act to suppress 
      alcohol intake by activating a Mitogen-Activated Protein Kinase (MAPK)-dependent 
      genomic mechanism. We further provide data to suggest that alcohol intake levels 
      escalate when the endogenous corticostriatal BDNF pathway becomes dysregulated. 
      Finally, we summarize recent studies suggesting that specific microRNAs targeting 
      BDNF mRNA in the medial prefrontal cortex (mPFC) regulate the breakdown of the 
      protective corticostriatal BDNF pathway.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Logrip, Marian L
AU  - Logrip ML
AD  - Committee on the Neurobiology of Addictive Disorders, The Scripps Research 
      Institute, La Jolla, CA, USA.
FAU - Barak, Segev
AU  - Barak S
AD  - School of Psychological Sciences and the Sagol School of Neuroscience, Tel Aviv 
      University, Tel Aviv, Israel.
FAU - Warnault, Vincent
AU  - Warnault V
AD  - Department of Neurology, University of California San Francisco, San Francisco, 
      CA, USA.
FAU - Ron, Dorit
AU  - Ron D
AD  - Department of Neurology, University of California San Francisco, San Francisco, 
      CA, USA. Electronic address: dorit.ron@ucsf.edu.
LA  - eng
GR  - R01 AA014366/AA/NIAAA NIH HHS/United States
GR  - R01 AA016848/AA/NIAAA NIH HHS/United States
GR  - K99 AA021802/AA/NIAAA NIH HHS/United States
GR  - R00 AA021802/AA/NIAAA NIH HHS/United States
GR  - R37 AA016848/AA/NIAAA NIH HHS/United States
GR  - P50 AA017072/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150321
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcoholism/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Central Nervous System Depressants/pharmacology
MH  - Cerebral Cortex/drug effects/*metabolism
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Ethanol/pharmacology
MH  - Neural Pathways/drug effects/metabolism
PMC - PMC4577309
MID - NIHMS674377
OTO - NOTNLM
OT  - Alcohol
OT  - BDNF
OT  - Dorsal striatum
OT  - Prefrontal cortex
EDAT- 2015/03/25 06:00
MHDA- 2016/09/28 06:00
PMCR- 2016/12/02
CRDT- 2015/03/25 06:00
PHST- 2014/10/10 00:00 [received]
PHST- 2015/02/03 00:00 [revised]
PHST- 2015/03/12 00:00 [accepted]
PHST- 2015/03/25 06:00 [entrez]
PHST- 2015/03/25 06:00 [pubmed]
PHST- 2016/09/28 06:00 [medline]
PHST- 2016/12/02 00:00 [pmc-release]
AID - S0006-8993(15)00221-8 [pii]
AID - 10.1016/j.brainres.2015.03.025 [doi]
PST - ppublish
SO  - Brain Res. 2015 Dec 2;1628(Pt A):60-7. doi: 10.1016/j.brainres.2015.03.025. Epub 
      2015 Mar 21.