PMID- 25801526 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20190610 IS - 1559-1182 (Electronic) IS - 0893-7648 (Print) IS - 0893-7648 (Linking) VI - 53 IP - 3 DP - 2016 Apr TI - The Role of 7,8-Dihydroxyflavone in Preventing Dendrite Degeneration in Cortex After Moderate Traumatic Brain Injury. PG - 1884-1895 LID - 10.1007/s12035-015-9128-z [doi] AB - Our previous research showed that traumatic brain injury (TBI) induced by controlled cortical impact (CCI) not only causes massive cell death, but also results in extensive dendrite degeneration in those spared neurons in the cortex. Cell death and dendrite degeneration in the cortex may contribute to persistent cognitive, sensory, and motor dysfunction. There is still no approach available to prevent cells from death and dendrites from degeneration following TBI. When we treated the animals with a small molecule, 7,8-dihydroxyflavone (DHF) that mimics the function of brain-derived neurotrophic factor (BDNF) through provoking TrkB activation reduced dendrite swellings in the cortex. DHF treatment also prevented dendritic spine loss after TBI. Functional analysis showed that DHF improved rotarod performance on the third day after surgery. These results suggest that although DHF treatment did not significantly reduced neuron death, it prevented dendrites from degenerating and protected dendritic spines against TBI insult. Consequently, DHF can partially improve the behavior outcomes after TBI. FAU - Zhao, Shu AU - Zhao S AD - Department of Histology and Embryology, Southern Medical University, Guangzhou, China. FAU - Gao, Xiang AU - Gao X AD - Spinal Cord and Brain Injury Research Group, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA. AD - Stark Neuroscience Research Institute, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA. AD - Department of Neurosurgery, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA. FAU - Dong, Weiren AU - Dong W AD - Department of Histology and Embryology, Southern Medical University, Guangzhou, China. wrdong@163.com. AD - , 1838 North Guangzhou Blvd, Guangzhou, 510515, China. wrdong@163.com. FAU - Chen, Jinhui AU - Chen J AD - Spinal Cord and Brain Injury Research Group, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA. chen204@iupui.edu. AD - Stark Neuroscience Research Institute, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA. chen204@iupui.edu. AD - Department of Neurosurgery, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA. chen204@iupui.edu. AD - Indiana University, School of Medicine, 980 W. Walnut Street, R3, Indianapolis, IN, 46202, USA. chen204@iupui.edu. LA - eng GR - UL1 RR025761/RR/NCRR NIH HHS/United States GR - 1R21NS072631-01A/NS/NINDS NIH HHS/United States GR - R21 NS075733/NS/NINDS NIH HHS/United States GR - UL1 TR001108/TR/NCATS NIH HHS/United States GR - RR025761/RR/NCRR NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20150324 PL - United States TA - Mol Neurobiol JT - Molecular neurobiology JID - 8900963 RN - 0 (6,7-dihydroxyflavone) RN - 0 (Flavones) RN - 0 (Neuroprotective Agents) SB - IM MH - Animals MH - Behavior, Animal/drug effects MH - Brain Injuries, Traumatic/complications/*drug therapy/pathology/physiopathology MH - Cerebral Cortex/*pathology MH - Dendrites MH - Flavones/pharmacology/*therapeutic use MH - Male MH - Maze Learning/drug effects MH - Memory/drug effects MH - Mice, Inbred C57BL MH - Nerve Degeneration/*drug therapy/pathology/physiopathology/*prevention & control MH - Neuroprotective Agents/pharmacology/therapeutic use PMC - PMC5441052 MID - NIHMS853951 OTO - NOTNLM OT - 7,8-Dihydroxyflavone OT - Brain-derived neurotrophic factor OT - Degeneration OT - Dendrite OT - Traumatic brain injury COIS- Conflict of interest The authors declare that there is no conflict of interest. EDAT- 2015/03/25 06:00 MHDA- 2016/12/15 06:00 PMCR- 2017/05/23 CRDT- 2015/03/25 06:00 PHST- 2014/10/20 00:00 [received] PHST- 2015/02/22 00:00 [accepted] PHST- 2015/03/25 06:00 [entrez] PHST- 2015/03/25 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] PHST- 2017/05/23 00:00 [pmc-release] AID - 10.1007/s12035-015-9128-z [pii] AID - 10.1007/s12035-015-9128-z [doi] PST - ppublish SO - Mol Neurobiol. 2016 Apr;53(3):1884-1895. doi: 10.1007/s12035-015-9128-z. Epub 2015 Mar 24.