PMID- 25802152
OWN - NLM
STAT- MEDLINE
DCOM- 20160105
LR  - 20231213
IS  - 1879-0445 (Electronic)
IS  - 0960-9822 (Linking)
VI  - 25
IP  - 7
DP  - 2015 Mar 30
TI  - Functional divergence of type 2 deiodinase paralogs in the Atlantic salmon.
PG  - 936-41
LID - S0960-9822(15)00149-9 [pii]
LID - 10.1016/j.cub.2015.01.074 [doi]
AB  - Thyroid hormone (TH) is an ancestral signal linked to seasonal life history 
      transitions throughout vertebrates. TH action depends upon tissue-localized 
      regulation of levels of active TH (triiodothyronine, T3), through spatiotemporal 
      expression of thyroid hormone deiodinase (dio) genes. We investigated the dio 
      gene family in juvenile Atlantic salmon (Salmo salar) parr, which prepare for 
      seaward migration in the spring (smoltification) through TH-dependent changes in 
      physiology. We identified two type 2 deiodinase paralogs, dio2a and dio2b, 
      responsible for conversion of thyroxine (T4) to T3. During smoltification, dio2b 
      was induced in the brain and gills in zones of cell proliferation following 
      increasing day length. Contrastingly, dio2a expression was induced in the gills 
      by transfer to salt water (SW), with the magnitude of the response proportional 
      to the plasma chloride level. This response reflected a selective enrichment for 
      osmotic response elements (OREs) in the dio2a promoter region. Transcriptomic 
      profiling of gill tissue from fish transferred to SW plus or minus the deiodinase 
      inhibitor, iopanoic acid, revealed SW-induced increases in cellular respiration 
      as the principal consequence of gill dio2 activity. Divergent evolution of dio2 
      paralogs supports organ-specific timing of the TH-dependent events governing the 
      phenotypic plasticity required for migration to sea.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Lorgen, Marlene
AU  - Lorgen M
AD  - Institute of Biological and Environmental Sciences, University of Aberdeen, 
      Aberdeen AB24 2TZ, UK.
FAU - Casadei, Elisa
AU  - Casadei E
AD  - Institute of Biological and Environmental Sciences, University of Aberdeen, 
      Aberdeen AB24 2TZ, UK.
FAU - Krol, Elzbieta
AU  - Krol E
AD  - Institute of Biological and Environmental Sciences, University of Aberdeen, 
      Aberdeen AB24 2TZ, UK.
FAU - Douglas, Alex
AU  - Douglas A
AD  - Institute of Biological and Environmental Sciences, University of Aberdeen, 
      Aberdeen AB24 2TZ, UK.
FAU - Birnie, Mike J
AU  - Birnie MJ
AD  - Institute of Biological and Environmental Sciences, University of Aberdeen, 
      Aberdeen AB24 2TZ, UK.
FAU - Ebbesson, Lars O E
AU  - Ebbesson LO
AD  - Uni Research Environment, Uni Research AS, Thormohlensgt 49B, 5006 Bergen, 
      Norway.
FAU - Nilsen, Tom O
AU  - Nilsen TO
AD  - Uni Research Environment, Uni Research AS, Thormohlensgt 49B, 5006 Bergen, 
      Norway.
FAU - Jordan, William C
AU  - Jordan WC
AD  - Zoological Society London, Institute of Zoology, London NW1 4RY, UK.
FAU - Jorgensen, Even H
AU  - Jorgensen EH
AD  - Department of Arctic and Marine Biology, Faculty of BioSciences, Fisheries and 
      Economy, University of Tromso, 9037 Tromso, Norway.
FAU - Dardente, Hugues
AU  - Dardente H
AD  - INRA UMR85, CNRS UMR7247, Universite de Tours, IFCE, 37380 Nouzilly, France.
FAU - Hazlerigg, David G
AU  - Hazlerigg DG
AD  - Institute of Biological and Environmental Sciences, University of Aberdeen, 
      Aberdeen AB24 2TZ, UK; Department of Arctic and Marine Biology, Faculty of 
      BioSciences, Fisheries and Economy, University of Tromso, 9037 Tromso, Norway. 
      Electronic address: david.hazlerigg@uit.no.
FAU - Martin, Samuel A M
AU  - Martin SA
AD  - Institute of Biological and Environmental Sciences, University of Aberdeen, 
      Aberdeen AB24 2TZ, UK.
LA  - eng
SI  - GENBANK/KP851703
SI  - GENBANK/KP851704
SI  - GENBANK/KP851705
SI  - GENBANK/KP851706
SI  - GENBANK/KP851707
SI  - GENBANK/KP851708
GR  - BB/H008063/1/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150319
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Thyroid Hormones)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
CIN - Curr Biol. 2015 Apr 20;25(8):R344-7. PMID: 25898108
MH  - Animals
MH  - Gills/growth & development/*metabolism
MH  - Iodide Peroxidase/genetics/*metabolism
MH  - Life Cycle Stages/genetics/*physiology
MH  - Molecular Sequence Data
MH  - Osmotic Pressure
MH  - Salmo salar/*growth & development
MH  - Seasons
MH  - Thyroid Hormones/genetics/*metabolism
MH  - Thyroxine/metabolism
MH  - Triiodothyronine/metabolism
MH  - Iodothyronine Deiodinase Type II
EDAT- 2015/03/25 06:00
MHDA- 2016/01/06 06:00
CRDT- 2015/03/25 06:00
PHST- 2014/01/28 00:00 [received]
PHST- 2015/01/09 00:00 [revised]
PHST- 2015/01/30 00:00 [accepted]
PHST- 2015/03/25 06:00 [entrez]
PHST- 2015/03/25 06:00 [pubmed]
PHST- 2016/01/06 06:00 [medline]
AID - S0960-9822(15)00149-9 [pii]
AID - 10.1016/j.cub.2015.01.074 [doi]
PST - ppublish
SO  - Curr Biol. 2015 Mar 30;25(7):936-41. doi: 10.1016/j.cub.2015.01.074. Epub 2015 
      Mar 19.