PMID- 25802930
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20220129
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 56
IP  - 4
DP  - 2015 Apr
TI  - Quantitative magnetic resonance imaging evidence for altered structural 
      remodeling of the temporal lobe in West syndrome.
PG  - 608-16
LID - 10.1111/epi.12907 [doi]
AB  - OBJECTIVE: To explore the structure-function relation of the temporal lobe in 
      newly diagnosed West syndrome of unknown cause (uWS). METHODS: Quantitative 
      magnetic resonance imaging (three-dimensional [3D] structural MRI and diffusion 
      tensor imaging [DTI]) was analyzed using voxel-based morphometry (VBM) and 
      tract-based spatial statistics (TBSS) in 22 patients and healthy age-matched 
      controls. The electrophysiologic responsiveness of the temporal lobe was measured 
      using the N100 auditory event-related potential (aERP) to a repeated 1,000 Hz 
      tone. Neurocognitive function was assessed using the Bayley Scales of Infant 
      Development, Second Edition (BSID-II). Tests followed first-line treatment with 
      vigabatrin (17 patients) or high-dose oral prednisolone (5 patients). RESULTS: 
      Total temporal lobe volume was similar in patients and controls. Patients had a 
      smaller temporal stem (TS) (p < 0.0001) and planum temporale (PT) (p = 0.029) 
      bilaterally. TS width asymmetry with a larger right-sided width in controls was 
      absent in patients (p = 0.033). PT asymmetry was present in both groups, being 
      larger on the right (p = 0.048). VBM gray matter volume was increased at the left 
      temporal lobe (superior and middle temporal gyri, the peri-rhinal cortex, and 
      medial temporal lobe) (p < 0.005, family wise error-corrected). VBM gray matter 
      volume correlated with the duration of infantile spasms (Pearson's r = -0.630, p 
      = 0.009). DTI metrics did not differ between patients and controls on TBSS. Mean 
      BSID-II scores were lower (p < 0.001) and auditory N100 ERP attenuated less in 
      patients than in controls (p = 0.002). SIGNIFICANCE: The functional networking 
      and white matter development of the temporal lobe are impaired following 
      infantile spasms. Treatment may promote structural plasticity within the temporal 
      lobe following infantile spasms, manifest as increased gray matter volume on VBM. 
      It remains to be investigated further whether this predicts patients' long-term 
      cognitive difficulties.
CI  - (c) 2015 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of 
      International League Against Epilepsy.
FAU - Fosi, Tangunu
AU  - Fosi T
AD  - Young Epilepsy, Surrey, United Kingdom; Department of Clinical Neurophysiology, 
      Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom; 
      Neurosciences Unit, University College London Institute of Child Health, London, 
      United Kingdom.
FAU - Chu, Carlton
AU  - Chu C
FAU - Chong, Wui Khean
AU  - Chong WK
FAU - Clark, Chris
AU  - Clark C
FAU - Scott, Rod C
AU  - Scott RC
FAU - Boyd, Stewart
AU  - Boyd S
FAU - De Haan, Michelle
AU  - De Haan M
FAU - Neville, Brian
AU  - Neville B
LA  - eng
GR  - G1002276/MRC_/Medical Research Council/United Kingdom
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150302
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Prospective Studies
MH  - Registries
MH  - Spasms, Infantile/*diagnosis/*genetics/metabolism
MH  - Temporal Lobe/metabolism/*pathology
PMC - PMC5006860
OTO - NOTNLM
OT  - Auditory event-related potential
OT  - Quantitative magnetic resonance imaging
OT  - Temporal lobe
OT  - West syndrome
EDAT- 2015/03/25 06:00
MHDA- 2015/06/16 06:00
PMCR- 2016/08/31
CRDT- 2015/03/25 06:00
PHST- 2014/11/30 00:00 [accepted]
PHST- 2015/03/25 06:00 [entrez]
PHST- 2015/03/25 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
PHST- 2016/08/31 00:00 [pmc-release]
AID - EPI12907 [pii]
AID - 10.1111/epi.12907 [doi]
PST - ppublish
SO  - Epilepsia. 2015 Apr;56(4):608-16. doi: 10.1111/epi.12907. Epub 2015 Mar 2.