PMID- 25803994
OWN - NLM
STAT- MEDLINE
DCOM- 20150429
LR  - 20190221
IS  - 2578-742X (Print)
IS  - 2578-742X (Linking)
VI  - 36
IP  - 6
DP  - 2014 Dec
TI  - Metastatic lung adenocarcinoma to the kidney diagnosed by urine cytology: a case 
      report.
PG  - 345-50
AB  - BACKGROUND: Although lung cancer is the solid tumor which most frequently 
      metastasizes to the kidney, metastatic pulmonary adenocarcinoma detected by urine 
      cytology examination is exceedingly rare. CASE: A 52-year-old woman presented 
      with gross hematuria. Urine cytology revealed numerous crowded, overlapped 
      3-dimensional clusters with occasional papillary and luminal formations. The 
      tumor nuclei were uniformly enlarged with smooth oval contours, regular nuclear 
      membranes, finely granular chromatin, and prominent nucleoli. Numerous clear, 
      intracytoplasmic vacuoles were noted. Urine fluorescence in situ hybridization 
      (FISH) examination was abnormal. Positive immunohistochemical thyroglobulin 
      transcription factor-1 and Napsin-A staining of a renal calyx biopsy confirmed 
      the diagnosis of metastatic lung cancer. CONCLUSION: Although rare, metastatic 
      lung adenocarcinoma in urine has characteristic cytomorphologic findings which 
      appear distinct from the more commonly encountered urothelial carcinoma. 
      Differentiation from other metastatic malignancies may be more problematic and 
      will likely require immunohistochemical confirmation. Metastatic lung cancer may 
      also cause abnormal urine FISH results and thus may be misdiagnosed as urothelial 
      cancer. Therefore, this ancillary testing modality must be employed with caution 
      in the setting of metastatic disease.
FAU - Tauchi-Nishi, Pamela
AU  - Tauchi-Nishi P
FAU - Sae-ow, Wichit
AU  - Sae-ow W
FAU - Kaneshiro, Ricky
AU  - Kaneshiro R
FAU - Lyon, Blake
AU  - Lyon B
FAU - Morris, Paul
AU  - Morris P
FAU - Lum, Christopher
AU  - Lum C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Anal Quant Cytopathol Histpathol
JT  - Analytical and quantitative cytopathology and histopathology
JID - 101638882
SB  - IM
MH  - Adenocarcinoma/genetics/pathology/*urine
MH  - Adenocarcinoma of Lung
MH  - *Chromosome Aberrations
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/genetics/pathology/secondary/*urine
MH  - Lung Neoplasms/genetics/pathology/*urine
MH  - Middle Aged
EDAT- 2015/03/26 06:00
MHDA- 2015/04/30 06:00
CRDT- 2015/03/26 06:00
PHST- 2015/03/26 06:00 [entrez]
PHST- 2015/03/26 06:00 [pubmed]
PHST- 2015/04/30 06:00 [medline]
PST - ppublish
SO  - Anal Quant Cytopathol Histpathol. 2014 Dec;36(6):345-50.