PMID- 25804415
OWN - NLM
STAT- MEDLINE
DCOM- 20160517
LR  - 20220408
IS  - 1549-9642 (Electronic)
IS  - 1549-9634 (Linking)
VI  - 11
IP  - 6
DP  - 2015 Aug
TI  - Advances in drug delivery systems (DDSs) to release growth factors for wound 
      healing and skin regeneration.
PG  - 1551-73
LID - S1549-9634(15)00075-1 [pii]
LID - 10.1016/j.nano.2015.03.002 [doi]
AB  - Current advances in novel drug delivery systems (DDSs) to release growth factors 
      (GFs) represent a great opportunity to develop new therapies or enhance the 
      effectiveness of available medical treatments. These advances are particularly 
      relevant to the field of regenerative medicine, challenging healthcare issues 
      such as wound healing and skin repair. To this end, biocompatible biomaterials 
      have been extensively studied to improve in vivo integration of DDSs, to enhance 
      the bioactivity of the released drugs and to deliver bioactive molecules in a 
      localised and controlled manner. Thus, this review presents an overview of DDSs 
      to release GFs for skin regeneration, particularly emphasising on (i) polymeric 
      micro and nanospheres, (ii) lipid nanoparticles, (iii) nanofibrous structures, 
      (iv) hydrogels and (v) scaffolds. In addition, this review summarises the current 
      animal models available for studying wound healing and the clinical trials and 
      marketed medications based on GF administration indicated for chronic wound 
      treatment. FROM THE CLINICAL EDITOR: Chronic wounds currently pose a significant 
      burden worldwide. With advances in science, novel drug delivery systems have been 
      developed for growth factors delivery. In this comprehensive review, the authors 
      highlighted current drug delivery systems for the enhancement of wound healing 
      and their use in clinical settings.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Gainza, Garazi
AU  - Gainza G
AD  - NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of 
      the Basque Country, Vitoria, Spain; Biomedical Research Networking Centre in 
      Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain.
FAU - Villullas, Silvia
AU  - Villullas S
AD  - Biopraxis Research AIE, Minano 01510, Spain.
FAU - Pedraz, Jose Luis
AU  - Pedraz JL
AD  - NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of 
      the Basque Country, Vitoria, Spain; Biomedical Research Networking Centre in 
      Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain.
FAU - Hernandez, Rosa Maria
AU  - Hernandez RM
AD  - NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of 
      the Basque Country, Vitoria, Spain; Biomedical Research Networking Centre in 
      Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain.
FAU - Igartua, Manoli
AU  - Igartua M
AD  - NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of 
      the Basque Country, Vitoria, Spain; Biomedical Research Networking Centre in 
      Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain. 
      Electronic address: manoli.igartua@ehu.es.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150321
PL  - United States
TA  - Nanomedicine
JT  - Nanomedicine : nanotechnology, biology, and medicine
JID - 101233142
RN  - 0 (Growth Substances)
SB  - IM
MH  - Animals
MH  - *Drug Delivery Systems
MH  - Growth Substances/*administration & dosage
MH  - Humans
MH  - *Regeneration
MH  - Skin/*physiopathology
MH  - *Wound Healing
OTO - NOTNLM
OT  - Drug delivery system
OT  - Growth factor
OT  - Microparticle
OT  - Nanosphere
OT  - Skin regeneration
OT  - Wound healing
EDAT- 2015/03/26 06:00
MHDA- 2016/05/18 06:00
CRDT- 2015/03/26 06:00
PHST- 2014/10/10 00:00 [received]
PHST- 2015/03/03 00:00 [revised]
PHST- 2015/03/03 00:00 [accepted]
PHST- 2015/03/26 06:00 [entrez]
PHST- 2015/03/26 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
AID - S1549-9634(15)00075-1 [pii]
AID - 10.1016/j.nano.2015.03.002 [doi]
PST - ppublish
SO  - Nanomedicine. 2015 Aug;11(6):1551-73. doi: 10.1016/j.nano.2015.03.002. Epub 2015 
      Mar 21.