PMID- 25804841
OWN - NLM
STAT- MEDLINE
DCOM- 20160224
LR  - 20181113
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 102
IP  - 1
DP  - 2015 Jul
TI  - Cell adhesion down-regulates the expression of vacuolar protein sorting 4B 
      (VPS4B) and contributes to drug resistance in multiple myeloma cells.
PG  - 25-34
LID - 10.1007/s12185-015-1783-3 [doi]
AB  - The expression and biologic function of the gene encoding vacuolar protein 
      sorting 4B (VPS4B) in human multiple myeloma (MM) were investigated in this 
      study. We determined that VPS4B expression is decreased in adherent MM cells and 
      that knockdown of VPS4B expression induces cell adhesion-mediated drug resistance 
      (CAM-DR) in MM. This induced CAM-DR phenotype manifested through down-regulation 
      of cell apoptosis and requires phosphorylation of AKT and Erk. Finally, VPS4B 
      expression was positively correlated with cell proliferation. Our findings 
      support a role for VPS4B in MM cell proliferation, adhesion, and drug resistance, 
      and pave the way for a novel therapeutic approach targeting this molecule.
FAU - Tang, Jie
AU  - Tang J
AD  - Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, 
      Medical College, Nantong University, Nantong, Jiangsu Province, 226001, People's 
      Republic of China.
FAU - Ji, Lili
AU  - Ji L
FAU - Wang, Yuchan
AU  - Wang Y
FAU - Huang, Yuejiao
AU  - Huang Y
FAU - Yin, Haibing
AU  - Yin H
FAU - He, Yunhua
AU  - He Y
FAU - Liu, Jing
AU  - Liu J
FAU - Miao, Xiaobing
AU  - Miao X
FAU - Wu, Yaxun
AU  - Wu Y
FAU - Xu, Xiaohong
AU  - Xu X
FAU - He, Song
AU  - He S
FAU - Cheng, Chun
AU  - Cheng C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150325
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Endosomal Sorting Complexes Required for Transport)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - EC 3.6.4.- (ATPases Associated with Diverse Cellular Activities)
RN  - EC 3.6.4.6 (VPS4B protein, human)
SB  - IM
MH  - ATPases Associated with Diverse Cellular Activities
MH  - Adenosine Triphosphatases/*genetics/metabolism
MH  - Apoptosis/genetics
MH  - Cell Adhesion/genetics
MH  - Cell Line, Tumor
MH  - Down-Regulation
MH  - Drug Resistance, Neoplasm/*genetics
MH  - Endosomal Sorting Complexes Required for Transport/*genetics/metabolism
MH  - *Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Multiple Myeloma/drug therapy/*genetics/metabolism
MH  - Phenotype
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-akt
EDAT- 2015/03/26 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/03/26 06:00
PHST- 2014/08/07 00:00 [received]
PHST- 2015/03/17 00:00 [accepted]
PHST- 2015/03/09 00:00 [revised]
PHST- 2015/03/26 06:00 [entrez]
PHST- 2015/03/26 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - 10.1007/s12185-015-1783-3 [doi]
PST - ppublish
SO  - Int J Hematol. 2015 Jul;102(1):25-34. doi: 10.1007/s12185-015-1783-3. Epub 2015 
      Mar 25.