PMID- 25805052
OWN - NLM
STAT- MEDLINE
DCOM- 20160217
LR  - 20240227
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Print)
IS  - 0736-5748 (Linking)
VI  - 43
DP  - 2015 Jun
TI  - Effects of developmental alcohol exposure vs. intubation stress on BDNF and TrkB 
      expression in the hippocampus and frontal cortex of neonatal rats.
PG  - 16-24
LID - S0736-5748(15)00036-2 [pii]
LID - 10.1016/j.ijdevneu.2015.03.008 [doi]
AB  - Third trimester-equivalent alcohol exposure causes significant deficits in 
      hippocampal and cortical neuroplasticity, resulting in alterations to dendritic 
      arborization, hippocampal adult neurogenesis, and performance on learning tasks. 
      The current study investigated the impact of neonatal alcohol exposure (postnatal 
      days 4-9, 5.25 g/kg/day) on expression of brain-derived neurotrophic factor 
      (BDNF) and the tropomyosin-related kinase B (TrkB) receptor in the hippocampal 
      and frontal cortex of infant Long-Evans rats. Levels of BDNF protein were 
      increased in the hippocampus, but not frontal cortex, of alcohol-exposed rats 24h 
      after the last dose, when compared with undisturbed (but not sham-intubated) 
      control animals. BDNF protein levels showed a trend toward increase in 
      hippocampus of sham-intubated animals as well, suggesting an effect of the 
      intubation procedure. TrkB protein was increased in the hippocampus of 
      alcohol-exposed animals compared to sham-intubated pups, indicating an 
      alcohol-specific effect on receptor expression. In addition, expression of bdnf 
      total mRNA in alcohol-exposed and sham-intubated pups was enhanced in the 
      hippocampus; however, there was a differential effect of alcohol and intubation 
      stress on exon I- and IV-specific mRNA transcripts. Further, plasma 
      corticosterone was found to be increased in both alcohol-exposed and 
      sham-intubated pups compared to undisturbed animals. Upregulation of BDNF could 
      potentially represent a neuroprotective mechanism activated following alcohol 
      exposure or stress. The results suggest that alcohol exposure and stress have 
      both overlapping and unique effects on BDNF, and highlight the need for the 
      stress of intubation to be taken into consideration in studies that implement 
      this route of drug delivery.
CI  - Copyright (c) 2015 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Boschen, K E
AU  - Boschen KE
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      DE 19716, United States.
FAU - Criss, K J
AU  - Criss KJ
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      DE 19716, United States.
FAU - Palamarchouk, V
AU  - Palamarchouk V
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      DE 19716, United States.
FAU - Roth, T L
AU  - Roth TL
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      DE 19716, United States.
FAU - Klintsova, A Y
AU  - Klintsova AY
AD  - Department of Psychological and Brain Sciences, University of Delaware, Newark, 
      DE 19716, United States. Electronic address: klintsov@udel.edu.
LA  - eng
GR  - P20 GM103653/GM/NIGMS NIH HHS/United States
GR  - 1P20GM103653-01A1/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150321
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (RNA, Messenger)
RN  - 3K9958V90M (Ethanol)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Central Nervous System Depressants/*adverse effects
MH  - Corticosterone/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Ethanol/*adverse effects
MH  - Female
MH  - Frontal Lobe/*drug effects/growth & development
MH  - Gene Expression Regulation, Developmental/*drug effects
MH  - Hippocampus/*drug effects/growth & development
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*pathology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptor, trkB/deficiency/*metabolism
MH  - Stress, Psychological/complications/pathology
PMC - PMC4442714
MID - NIHMS678244
OTO - NOTNLM
OT  - Cortex
OT  - Corticosterone
OT  - FASD
OT  - Neurotrophin
OT  - Plasticity
EDAT- 2015/03/26 06:00
MHDA- 2016/02/18 06:00
PMCR- 2016/06/01
CRDT- 2015/03/26 06:00
PHST- 2015/02/09 00:00 [received]
PHST- 2015/03/13 00:00 [revised]
PHST- 2015/03/14 00:00 [accepted]
PHST- 2015/03/26 06:00 [entrez]
PHST- 2015/03/26 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - S0736-5748(15)00036-2 [pii]
AID - 10.1016/j.ijdevneu.2015.03.008 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2015 Jun;43:16-24. doi: 10.1016/j.ijdevneu.2015.03.008. Epub 
      2015 Mar 21.