PMID- 25807534
OWN - NLM
STAT- MEDLINE
DCOM- 20160303
LR  - 20240326
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 3
DP  - 2015
TI  - H-index is important for postural control for people with impaired foot sole 
      sensation.
PG  - e0121847
LID - 10.1371/journal.pone.0121847 [doi]
LID - e0121847
AB  - INTRODUCTION: People with Peripheral Neuropathy (PN), especially those with 
      impaired sensory inputs through the small-afferent fiber (type II afferent 
      fibers) reflex loop (SAF), might depend more on the large-afferent fiber (type I 
      afferent fibers) reflex loop (LAF) for postural control. PURPOSE: To examine 
      whether the function of the LAF reflex loop, reflected by the H-reflex and ankle 
      joint proprioception, influences postural control when the SAF reflex loop is 
      impaired, as indicated by reduced foot sole cutaneous sensation. METHODS: 
      Thirteen participants (8 women, 5 men) diagnosed with PN and 12 age-matched 
      controls (7 women, 5 men) completed the testing protocol. Measures of interest 
      included the H-index, active (AAP) and passive (PAP) ankle proprioception, 
      plantar pressure sensitivity (PPS), average sway velocity (VAVG) and area (A95) 
      during 30 seconds eyes-closed standing, 6-minute walk distance (6MWD) and timed 
      up-and-go duration (TUG). RESULTS: Statistically significant group-dependent 
      regression was observed between VAVG and H-index. Compared to the control group, 
      the PN group demonstrated reduced PPS (2.0 +/- 1.9 vs. 4.2 +/- 1.2, P < .05) and 
      H-index (63.6 +/- 10.9 vs. 76.4 +/- 16.0, P < .05), greater VAVG (3.5 +/- 2.1 vs. 1.6 +/- 
      0.6 cm/s, P < .05) and A95 (10.0 +/- 10.1 vs. 2.5 +/- 1.5 cm2, P < .05), shorter 6MWD 
      (442.2 +/- 93.0 vs. 525.3 +/- 68.2 m, P < .05), and longer TUG (9.4 +/- 1.6 vs. 6.5 +/- 
      1.3 s, P < .05). Within the PN group, but not the control group, the H-index was 
      correlated with VAVG (r = -.56, P < .05). Moreover, within the PN group only, PAP 
      scores were correlated with 6MWD (r = -.68, P < .05) and TUG (r = -.59, P < .05) 
      performance. No other statistically significant group difference, correlation or 
      group-dependent regression was observed. CONCLUSION: VAVG, 6MWD, and TUG 
      correlated with LAF reflex loop function observed among those with impaired 
      functioning of the SAF reflex loop. This observation suggests that the LAF reflex 
      loop may be critical to the control of balance in those individuals suffering 
      from small-fiber PN.
FAU - Zhang, Shuqi
AU  - Zhang S
AD  - Louisiana State University, Baton Rouge, LA, United States of America; Georgia 
      Southern University, Statesboro, GA, United States of America.
FAU - Manor, Brad
AU  - Manor B
AD  - Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, United 
      States of America; Harvard Medical School, Boston, MA, United States of America; 
      Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA, United States of 
      America.
FAU - Li, Li
AU  - Li L
AD  - Georgia Southern University, Statesboro, GA, United States of America; Key 
      Laboratory of Exercise and Health Sciences, Ministry of Education, Shanghai 
      University of Sport, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20150325
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Ankle/physiopathology
MH  - Female
MH  - Foot/physiopathology
MH  - H-Reflex/*physiology
MH  - Humans
MH  - Hypesthesia/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Neural Conduction/physiology
MH  - Peripheral Nervous System Diseases/*physiopathology
MH  - Postural Balance/*physiology
MH  - Proprioception/*physiology
PMC - PMC4373754
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/03/26 06:00
MHDA- 2016/03/05 06:00
PMCR- 2015/03/25
CRDT- 2015/03/26 06:00
PHST- 2014/08/01 00:00 [received]
PHST- 2015/02/18 00:00 [accepted]
PHST- 2015/03/26 06:00 [entrez]
PHST- 2015/03/26 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
PHST- 2015/03/25 00:00 [pmc-release]
AID - PONE-D-14-33817 [pii]
AID - 10.1371/journal.pone.0121847 [doi]
PST - epublish
SO  - PLoS One. 2015 Mar 25;10(3):e0121847. doi: 10.1371/journal.pone.0121847. 
      eCollection 2015.