PMID- 25807634
OWN - NLM
STAT- MEDLINE
DCOM- 20150429
LR  - 20201019
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 61
IP  - 1-2
DP  - 2015
TI  - Imbalance of interleukin-18 and interleukin-18 binding protein in patients with 
      IgA nephropathy implicating renal vasculopathy.
PG  - 23-30
AB  - BACKGROUND: Interleukin-18 (IL-18) is a proinflammatory cytokine which induces 
      interferon-gamma production and plays a crucial role in immune systems. IL-18 binding 
      protein (IL-18BP) is a naturally occurring inhibitor of IL-18. The aim was to 
      investigate the involvement of IL-18 and IL-18BP in IgA nephropathy (IgAN). 
      METHODS: Serum samples from 21 IgAN patients and 16 idiopathic membranous 
      nephropathy (MN) patients and 32 healthy controls were assayed by an 
      enzyme-linked immunosorbent method. RESULTS: Compared to the controls, IgAN 
      patients showed significantly higher levels of IL-18 and the increased 
      IL-18/IL-18BP ratio. Despite IL-18 elevation, the levels of IL-18BP did not 
      parallel the increase of IL-18, which resulted in an increased IL-18/IL-18BP 
      ratio. Furthermore, the ratio in patients with renal vasculopathy was 
      significantly increased compared to those without arteriolar lesions. 
      CONCLUSIONS: These findings provide the first evidence that there is an imbalance 
      of IL-18/IL-18BP ratio in IgAN patients, which may be associated with the 
      pathophysiology of renal vasculopathy.
FAU - Shimizu, Chie
AU  - Shimizu C
FAU - Matsumoto, Koichi
AU  - Matsumoto K
FAU - Fujita, Takayuki
AU  - Fujita T
FAU - Fuke, Yoshinobu
AU  - Fuke Y
FAU - Soma, Masayoshi
AU  - Soma M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (IL18 protein, human)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin-18)
RN  - 0 (interleukin-18 binding protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arteriosclerosis/blood/pathology
MH  - Case-Control Studies
MH  - Female
MH  - Glomerulonephritis, IGA/*blood/pathology
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Interleukin-18/*blood
MH  - Kidney/blood supply/pathology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2015/03/27 06:00
MHDA- 2015/04/30 06:00
CRDT- 2015/03/27 06:00
PHST- 2015/03/27 06:00 [entrez]
PHST- 2015/03/27 06:00 [pubmed]
PHST- 2015/04/30 06:00 [medline]
AID - 10.7754/clin.lab.2014.140515 [doi]
PST - ppublish
SO  - Clin Lab. 2015;61(1-2):23-30. doi: 10.7754/clin.lab.2014.140515.