PMID- 25807652
OWN - NLM
STAT- MEDLINE
DCOM- 20150429
LR  - 20191113
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 61
IP  - 1-2
DP  - 2015
TI  - Elevated oxidative stress monitored via the albumin-thiol redox state is 
      correlated with matrix metalloproteinase-3 elevation in patients with rheumatoid 
      arthritis.
PG  - 175-8
AB  - BACKGROUND: In rheumatoid arthritis (RA), matrix metalloproteinase-3 (MMP-3) and 
      oxidative stress contribute to joint destruction. However, little is known about 
      the relationship between MMP-3 and oxidative stress in RA. METHODS: We measured 
      the albumin-thiol redox state as a marker of oxidative stress, MMP-3, and the 
      DAS-28 score calculated using CRP values among forty-seven patients (9 males and 
      38 females) with RA. According to the serum MMP-3 levels, they were divided into 
      two groups (group A: within normal ranges of 36.9-121.0 ng/mL for men and 
      17.3-59.7 ng/mL for women; group B: above normal ranges). RESULTS: The 
      albumin-thiol redox state in group B was significantly oxidized compared with 
      that in group A (p < 0.01). The percentage of oxidized albumin-thiol showed a 
      positive correlation with serum MMP-3 (r = 0.52). DAS-28 and CRP were also 
      correlated with the percentage of oxidized albumin-thiol (r = 0.46, r = 0.44). 
      CONCLUSIONS: The albumin-thiol redox state was significantly oxidized in 
      correlation with serum MMP-3 elevation in RA.
FAU - Kizaki, Kazuha
AU  - Kizaki K
FAU - Yoshizumi, Yusuke
AU  - Yoshizumi Y
FAU - Takahashi, Teppei
AU  - Takahashi T
FAU - Era, Seiichi
AU  - Era S
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Serum Albumin)
RN  - 0 (Sulfhydryl Compounds)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthritis, Rheumatoid/*enzymology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*metabolism
MH  - Middle Aged
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Serum Albumin/*metabolism
MH  - Sulfhydryl Compounds/metabolism
EDAT- 2015/03/27 06:00
MHDA- 2015/04/30 06:00
CRDT- 2015/03/27 06:00
PHST- 2015/03/27 06:00 [entrez]
PHST- 2015/03/27 06:00 [pubmed]
PHST- 2015/04/30 06:00 [medline]
AID - 10.7754/clin.lab.2014.140822 [doi]
PST - ppublish
SO  - Clin Lab. 2015;61(1-2):175-8. doi: 10.7754/clin.lab.2014.140822.