PMID- 2580944
OWN - NLM
STAT- MEDLINE
DCOM- 19850619
LR  - 20191101
VI  - 61
IP  - 3-4
DP  - 1985
TI  - Capsaicin and regulation of respiration: interaction with central substance P 
      mechanisms.
PG  - 239-52
AB  - The neuropharmacological effects of capsaicin (CAPS) 
      (8-methyl-N-vanillyl-6-nonenamide) have been closely linked to the peptide 
      neurotransmitter substance P (SP). In order to elucidate SP mechanisms in 
      peripheral and central control of breathing we have studied the respiratory 
      effects of CAPS and SP administration to neonatal and adult rats using a whole 
      body plethysmographic method. CAPS (3 and 30 micrograms) induced an immediate 
      apnea after intravenous injection. This effect could be reduced by vagotomy but 
      not further changed by combined vagotomy and glossopharyngectomy. The apnoic 
      periods were followed by periods of tachypnea. Intracerebroventricular (i.c.v.) 
      administration of CAPS resulted in an increased tidal volume (VT) and a decreased 
      respiratory frequency (f), i.e. a respiratory response similar to that seen after 
      i.c.v. SP. No apnoic episodes were seen after i.c.v. injection. The respiratory 
      pattern after acute i.c.v. CAPS administration was not significantly changed by 
      neonatal CAPS pretreatment. However, while saline pretreated control animals 
      responded to an i.c.v. injection of SP with an increase in VT and inspiratory 
      drive (VT/TI), animals pretreated with CAPS responded with a shortening of 
      inspiratory and expiratory time in combination with an increase in VT. Similar 
      changes have been observed in vagotomized animals after SP administration. It is 
      concluded that CAPS elicits apnea via mechanisms located outside the CNS, which 
      cannot be fully deafferented by combined vagotomy and glossopharyngectomy. 
      Furthermore, CAPS i.c.v. induces a stimulation of respiration by a central 
      mechanism of action, possibly due to a release of SP. Neonatal pretreatment with 
      CAPS modifies the respiratory response to i.c.v. SP. This effect might be due to 
      an impairment in tonical afferent SP mechanisms to the central respiratory 
      regulating system and possibly also to an impairment of central SP mechanisms 
      involved in respiration.
FAU - Hedner, J
AU  - Hedner J
FAU - Hedner, T
AU  - Hedner T
FAU - Jonason, J
AU  - Jonason J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - J Neural Transm
JT  - Journal of neural transmission
JID - 0337042
RN  - 33507-63-0 (Substance P)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Blood Pressure/drug effects
MH  - Brain/*drug effects
MH  - Capsaicin/*pharmacology
MH  - Female
MH  - Glossopharyngeal Nerve/physiology
MH  - Heart Rate/drug effects
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Respiration/*drug effects
MH  - Substance P/pharmacology
MH  - Vagus Nerve/physiology
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1007/BF01251915 [doi]
PST - ppublish
SO  - J Neural Transm. 1985;61(3-4):239-52. doi: 10.1007/BF01251915.