PMID- 25809705
OWN - NLM
STAT- MEDLINE
DCOM- 20150731
LR  - 20220331
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 36
IP  - 5
DP  - 2015 May
TI  - Oncocers: ceRNA-mediated cross-talk by sponging miRNAs in oncogenic pathways.
PG  - 3129-36
LID - 10.1007/s13277-015-3346-x [doi]
AB  - Competing endogenous RNAs (ceRNAs) are RNA transcripts which can communicate with 
      each other by decreasing targeting concentration of micro-RNA (miRNA) with the 
      derepression of other messenger RNAs (mRNAs) having the common miRNA response 
      elements (MREs). Oncocers are ceRNAs taking crucial roles in oncogenic pathways 
      processed in many types of cancer, and this study analyzes oncocer-mediated 
      cross-talk by sponging microRNAs (miRNAs) in these pathways. While doing this, 
      breast, liver, colon, prostate, gastric, lung, endometrium, thyroid and 
      epithelial cancers and melanoma, rhabdomyosarcoma, glioblastoma, acute 
      promyelocytic leukemia, retinoblastoma, and neuroblastoma were analyzed with 
      respect to ceRNA-based carcinogenesis. This study defines, firstly, oncocers in 
      the literature and contains all oncocer-related findings found up to now. 
      Therefore, it will help to increase our comprehension about oncocer-mediated 
      mechanisms. Via this study, a novel perspective would be produced to make clear 
      cancer mechanisms and suggest novel approaches to regulate ceRNA networks via 
      miRNA competition for cancer therapeutics. Graphical Abstract Multiple RNA 
      transcripts have common MREs for the similar miRNA in their 3'-untranslated 
      regions (3'-UTRs). Upregulation of ceRNAs rises the abundance of specific MREs 
      and shifts the miRNA pool distribution, as a result, leading to the increased 
      expression of target mRNA. The depot of genomic mutations and epigenetic 
      alterations changing gene function and expression causes cancers. Herewith, 
      genome-based somatic base-pair mutations, DNA copy number alterations, 
      chromosomal translocation, also transcript fusions, alternative splicing are 
      usually seen in cancer situations. Consequently, such cases causing changed UTR 
      expression in transcripts influence the levels of MRE or present new MREs into 
      the cells. Alterations in MREs of ceRNAs affect the capability of a specific mRNA 
      transcript to attach or titrate miRNAs. As a result, the disturbed ceRNA network 
      can lead to diseases and cancers. As a new term in RNA world, oncocers-the name 
      for ceRNAs taking crucial roles in oncogenic pathways-are processed in many types 
      of cancer, and oncocer-mediated cross-talk are analyzed by sponging miRNAs in 
      these pathways.
FAU - Ergun, Sercan
AU  - Ergun S
AD  - Ulubey Vocational Higher School, Ordu University, Ordu, Turkey, 
      sercanergun@msn.com.
FAU - Oztuzcu, Serdar
AU  - Oztuzcu S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150327
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - MicroRNAs/*physiology
MH  - Neoplasms/*genetics/metabolism
MH  - Oncogenes
MH  - RNA, Long Noncoding/physiology
EDAT- 2015/03/27 06:00
MHDA- 2015/08/01 06:00
CRDT- 2015/03/27 06:00
PHST- 2015/02/17 00:00 [received]
PHST- 2015/03/15 00:00 [accepted]
PHST- 2015/03/27 06:00 [entrez]
PHST- 2015/03/27 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
AID - 10.1007/s13277-015-3346-x [doi]
PST - ppublish
SO  - Tumour Biol. 2015 May;36(5):3129-36. doi: 10.1007/s13277-015-3346-x. Epub 2015 
      Mar 27.