PMID- 25809945
OWN - NLM
STAT- MEDLINE
DCOM- 20170425
LR  - 20181113
IS  - 1442-2050 (Electronic)
IS  - 1120-8694 (Print)
IS  - 1120-8694 (Linking)
VI  - 29
IP  - 6
DP  - 2016 Aug
TI  - High rate of galactose-alpha-1,3-galactose sensitization in both eosinophilic 
      esophagitis and patients undergoing upper endoscopy.
PG  - 558-62
LID - 10.1111/dote.12356 [doi]
AB  - Eosinophilic esophagitis (EoE) is an antigen/allergy-mediated chronic 
      inflammatory condition. The rapid rise in the number of cases of EoE suggests an 
      as-yet undiscovered environmental trigger. This study tested the hypothesis that 
      immunoglobulin E (IgE) to galactose-alpha-1,3-galactose (alpha-gal), a newly 
      recognized sensitization induced by a tick bite that causes mammalian meat 
      allergy, is a risk factor for EoE. We conducted a case-control study using 
      prospectively collected and stored samples in the University of North Carolina 
      EoE Patient Registry and Biobank. Serum from 50 subjects with a new diagnosis of 
      EoE and 50 non-EoE subjects (either with gastroesophageal reflux disease or 
      dysphagia from non-EoE etiologies) was tested for alpha-gal-specific IgE using an 
      ImmunoCAP-based method. Specific IgE > 0.35 kUA /L was considered a positive 
      result. Subjects with EoE were a mean of 35 years old, 68% were male, and 94% 
      were white. Non-EoE controls were a mean of 42 years, 50% were male, and 78% were 
      white. A total of 22 (22%) subjects overall had alpha-gal-specific IgE > 0.35 kUA 
      /L. Of the EoE cases, 12 (24%) were positive, and of the non-EoE controls, 10 
      (20%) were positive (p=0.63). Neither the proportion sensitized nor the absolute 
      values differed between EoE and non-EoE subjects. We found a similar but high 
      rate of alpha-gal sensitization in patients with EoE as found in non-EoE controls 
      who were undergoing endoscopy. While our data do not support alpha-gal 
      sensitization as a risk factor for EoE, the high rates of sensitization observed 
      in patients undergoing upper endoscopy for symptoms of esophageal dysfunction is 
      a new finding.
CI  - (c) 2015 International Society for Diseases of the Esophagus.
FAU - Burk, C M
AU  - Burk CM
AD  - Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and 
      Hepatology, Department of Medicine, University of North Carolina School of 
      Medicine, Chapel Hill, North Carolina, USA.
FAU - Beitia, R
AU  - Beitia R
AD  - Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and 
      Hepatology, Department of Medicine, University of North Carolina School of 
      Medicine, Chapel Hill, North Carolina, USA.
FAU - Lund, P K
AU  - Lund PK
AD  - Department of Cell Biology and Physiology, University of North Carolina School of 
      Medicine, Chapel Hill, North Carolina, USA.
AD  - Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and 
      Hepatology, Department of Medicine, University of North Carolina School of 
      Medicine, Chapel Hill, North Carolina, USA.
FAU - Dellon, E S
AU  - Dellon ES
AD  - Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and 
      Hepatology, Department of Medicine, University of North Carolina School of 
      Medicine, Chapel Hill, North Carolina, USA.
AD  - Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and 
      Hepatology, Department of Medicine, University of North Carolina School of 
      Medicine, Chapel Hill, North Carolina, USA.
LA  - eng
GR  - K23 DK090073/DK/NIDDK NIH HHS/United States
GR  - P30 DK034987/DK/NIDDK NIH HHS/United States
GR  - T35 DK007386/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20150323
PL  - United States
TA  - Dis Esophagus
JT  - Diseases of the esophagus : official journal of the International Society for 
      Diseases of the Esophagus
JID - 8809160
RN  - 0 (Disaccharides)
RN  - 13168-24-6 (galactosyl-(1-3)galactose)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Case-Control Studies
MH  - Deglutition Disorders/immunology/pathology
MH  - Disaccharides/*immunology
MH  - Endoscopy, Digestive System
MH  - Eosinophilic Esophagitis/*immunology/pathology
MH  - Female
MH  - Food Hypersensitivity/immunology
MH  - Gastroesophageal Reflux/immunology/pathology
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Meat
MH  - Middle Aged
PMC - PMC4580560
MID - NIHMS722641
OTO - NOTNLM
OT  - eosinophilic esophagitis
OT  - galactose-alpha-1,3-galactose
OT  - immunoglobulin E
COIS- Potential competing interests None of the other authors have any conflicts of 
      interest to disclose.
EDAT- 2015/03/27 06:00
MHDA- 2017/04/26 06:00
PMCR- 2017/08/01
CRDT- 2015/03/27 06:00
PHST- 2015/03/27 06:00 [entrez]
PHST- 2015/03/27 06:00 [pubmed]
PHST- 2017/04/26 06:00 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - 10.1111/dote.12356 [doi]
PST - ppublish
SO  - Dis Esophagus. 2016 Aug;29(6):558-62. doi: 10.1111/dote.12356. Epub 2015 Mar 23.