PMID- 25810479
OWN - NLM
STAT- MEDLINE
DCOM- 20160608
LR  - 20150905
IS  - 1753-9455 (Electronic)
IS  - 1753-9447 (Linking)
VI  - 9
IP  - 4
DP  - 2015 Aug
TI  - Early glucose variability in cardiogenic shock following acute myocardial 
      infarction: a pilot study.
PG  - 127-32
LID - 10.1177/1753944715578968 [doi]
AB  - BACKGROUND: No data are so far available on the association between glycaemic 
      variability and outcomes in patients with cardiogenic shock (CS) following ST 
      elevation myocardial infarction (STEMI). METHODS: We assessed the relationship 
      between glycaemic variability and mortality, both short term and long term, in 67 
      consecutive patients with cardiogenic shock following STEMI admitted to our 
      Intensive Cardiac Care Unit. Glycaemic variability was measured in the first 48 h 
      by means of standard deviation (SD) of glucose values and the mean absolute 
      glucose change per hour (MAGC) defined as the sum of all absolute glucose change 
      divided by the time in hours. RESULTS: Lower glycaemic variability was observed 
      in survivors when compared with nonsurvivors, as indicated by lower values of SD 
      and MAGC, respectively. In Cox regression analysis, MAGC and SD were independent 
      predictors of death (MAGC: adjusted hazard ratio [HR]: 8.60, 95% confidence 
      interval [CI]: 2.21-33.41, p = 0.002; SD: adjusted HR: 6.64, 95% CI: 1.92-22.99, 
      p = 0.003), as well as peak glycaemia (adjusted HR: 1.95, 95% CI: 1.20-3.15, p = 
      0.007). CONCLUSIONS: According to our results, in patients with CS following 
      acute myocardial infarction, early glycaemic variability is an independent 
      predictor of mortality. Further studies are needed to confirm our results in 
      larger cohorts and eventually to assess the effect of strategies specifically 
      targeting glucose variability reduction on mortality.
CI  - (c) The Author(s), 2015.
FAU - Lazzeri, Chiara
AU  - Lazzeri C
AD  - Intensive Cardiac Care Unit, Heart and Vessel Department, Viale Morgagni 85, 
      50134 Florence, Italy lazzeric@libero.it.
FAU - Valente, Serafina
AU  - Valente S
AD  - Intensive Cardiac Care Unit, Heart and Vessel Department, Florence, Italy.
FAU - Chiostri, Marco
AU  - Chiostri M
AD  - Intensive Cardiac Care Unit, Heart and Vessel Department, Florence, Italy.
FAU - Attana, Paola
AU  - Attana P
AD  - Intensive Cardiac Care Unit, Heart and Vessel Department, Florence, Italy.
FAU - Gensini, Gian Franco
AU  - Gensini GF
AD  - Intensive Cardiac Care Unit, Heart and Vessel Department, Florence, Italy and 
      Department of Experimental and Clinical Medicine, University of Florence, 
      Florence, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150325
PL  - England
TA  - Ther Adv Cardiovasc Dis
JT  - Therapeutic advances in cardiovascular disease
JID - 101316343
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*complications/mortality
MH  - Pilot Projects
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Shock, Cardiogenic/*etiology/mortality
MH  - Time Factors
OTO - NOTNLM
OT  - ST elevation myocardial infarction
OT  - cardiogenic shock
OT  - glucose values
OT  - glycaemic variability
OT  - mortality
EDAT- 2015/03/27 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/03/27 06:00
PHST- 2015/03/27 06:00 [entrez]
PHST- 2015/03/27 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - 1753944715578968 [pii]
AID - 10.1177/1753944715578968 [doi]
PST - ppublish
SO  - Ther Adv Cardiovasc Dis. 2015 Aug;9(4):127-32. doi: 10.1177/1753944715578968. 
      Epub 2015 Mar 25.