PMID- 25810882
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150326
LR  - 20200930
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 18
IP  - 1
DP  - 2015 Jan
TI  - Time course changes of oxidative stress and inflammation in hyperoxia-induced 
      acute lung injury in rats.
PG  - 98-103
AB  - OBJECTIVES: Therapies with high levels of oxygen are commonly used in the 
      management of critical care. However, prolonged exposure to hyperoxia can cause 
      acute lung injury. Although oxidative stress and inflammation are purported to 
      play an important role in the pathogenesis of acute lung injury, the exact 
      mechanisms are still less known in the hyperoxic acute lung injury (HALI). 
      MATERIALS AND METHODS: In this study, we investigated the time course changes of 
      oxidative stress and inflammation in lung tissues of rats exposed to >95% oxygen 
      for 12-60 hr. RESULTS: We found that at 12 hr after hyperoxia challenge, the 
      activities of superoxide dismutase and glutathione peroxidase were significantly 
      reduced with remarkably increased lipid peroxidation. At 12 hr, NF-kappaB p65 
      expression was also upregulated, but Ikappa-Balpha expression showed a remarkable 
      decline. Significant production of inflammatory mediators, e.g, interleukin-1beta, 
      occurred 24 hr after hyperoxia exposure. In addition, the expression of 
      intracellular adhesion molecule 1 expression and the activity of myeloperoxidase 
      were significantly increased at 24 hr with a peak at 48 hr. CONCLUSION: Our data 
      support that hyperoxia-induced oxidative damage and NF-kappaB pathway activation 
      implicate in the early phase of HALI pathogenesis.
FAU - Yu, Shouli
AU  - Yu S
AD  - Department of quality management, Yantai Yuhuangding Hospital Affiliated to 
      Qingdao University, Yantai City, Shandong Province, China.
FAU - Shi, Min
AU  - Shi M
AD  - Department of Nanlou, Respiratory Disease, Chinese PLA General Hospital, Beijing, 
      China.
FAU - Liu, Changting
AU  - Liu C
AD  - Department of Nanlou, Respiratory Disease, Chinese PLA General Hospital, Beijing, 
      China.
FAU - Liu, Qinghui
AU  - Liu Q
AD  - Department of Nanlou, Respiratory Disease, Chinese PLA General Hospital, Beijing, 
      China.
FAU - Guo, Jun
AU  - Guo J
AD  - Department of Nanlou, Respiratory Disease, Chinese PLA General Hospital, Beijing, 
      China.
FAU - Yu, Senyang
AU  - Yu S
AD  - Department of Nanlou, Respiratory Disease, Chinese PLA General Hospital, Beijing, 
      China.
FAU - Jiang, Tingshu
AU  - Jiang T
AD  - Respiratory Department, Yantai Yuhuangding Hospital Affiliated to Qingdao 
      University, Yantai City, Shandong Province, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
RIN - Iran J Basic Med Sci. 2019 Oct;22(10):1225. PMID: 31998467
PMC - PMC4366750
OTO - NOTNLM
OT  - Acute lung injury
OT  - Hyperoxia
OT  - Inflammation
OT  - Oxidative stress
EDAT- 2015/03/27 06:00
MHDA- 2015/03/27 06:01
PMCR- 2015/01/01
CRDT- 2015/03/27 06:00
PHST- 2014/01/28 00:00 [received]
PHST- 2014/05/25 00:00 [accepted]
PHST- 2015/03/27 06:00 [entrez]
PHST- 2015/03/27 06:00 [pubmed]
PHST- 2015/03/27 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - IJBMS-18-98 [pii]
PST - ppublish
SO  - Iran J Basic Med Sci. 2015 Jan;18(1):98-103.