PMID- 25812355
OWN - NLM
STAT- MEDLINE
DCOM- 20150417
LR  - 20220330
IS  - 1110-4902 (Print)
VI  - 21
IP  - 2
DP  - 2014
TI  - Vitamin D level among Egyptian patients with chronic spontaneous urticaria and 
      its relation to severity of the disease.
PG  - 85-90
AB  - Vitamin D has an important role in the immune system. Decreased serum vitamin D 
      level is known to be associated with autoimmune and atopic diseases. This study 
      aimed to assess vitamin D status in patients with chronic spontaneous urticaria 
      (CSU) and its relation with severity of the disease. This case-control study was 
      conducted on 22 patients and 20 age and sex matched controls. Patients were 
      subjected to clinical assessment, routine laboratory examination: complete blood 
      picture (CBC), erythrocyte sedimentation rate (ESR), hepatitis B surface antigen 
      (HBsAg), hepatitis C virus antibody (HCV Ab), anti-thyroid antibody, anti-nuclear 
      antibody (ANA), total immunoglobulin E (IgE), vitamin D assay and stool analysis, 
      and special investigations including: skin prick test (SPT), autologous serum 
      skin test (ASST) and urticaria activity score (UAS). Patients' mean age was 32.8 
      +/- 13.17 years. The median and interquartile range of duration of illness was 2.5 
      (1-4) years and of Ig E was 79 (62-312) IU/ml. According to UAS; 14 (63.6%) had 
      severe and 8 (36.4%) had moderate degree illness. The mean vitamin D level among 
      the patients was 28.4 +/- 9.09 nmol/L. Vitamin D level was significantly lower 
      among patients in comparison to controls (28.4 +/- 9.09 vs. 104.5 +/- 76.8, t = 4.4 P 
      < 0.01). Vitamin D correlated negatively with IgE level (r = -0.45, P < 0.05), 
      meanwhile it was insignificantly correlated with age and duration of illness (r = 
      -0.117 and 0.34 respectively, P > 0.05). In conclusion; Low vitamin D level (r = 
      0.45) is associated with chronic spontaneous urticaria but has no relation with 
      the severity of the disease.
FAU - Abdel-Rehim, Asmaa S M
AU  - Abdel-Rehim AS
FAU - Sheha, Dina S
AU  - Sheha DS
FAU - Mohamed, Nesrine A
AU  - Mohamed NA
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Egypt
TA  - Egypt J Immunol
JT  - The Egyptian journal of immunology
JID - 9816016
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Autoimmune Diseases/*blood/pathology
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Egypt
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - *Severity of Illness Index
MH  - Urticaria/*blood/mortality
MH  - Vitamin D/*blood
EDAT- 2014/01/01 00:00
MHDA- 2015/04/18 06:00
CRDT- 2015/03/28 06:00
PHST- 2015/03/28 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2015/04/18 06:00 [medline]
PST - ppublish
SO  - Egypt J Immunol. 2014;21(2):85-90.