PMID- 25812624
OWN - NLM
STAT- MEDLINE
DCOM- 20160930
LR  - 20240324
IS  - 1547-6901 (Electronic)
IS  - 1547-691X (Print)
IS  - 1547-691X (Linking)
VI  - 13
IP  - 2
DP  - 2016
TI  - Investigations of immunotoxicity and allergic potential induced by topical 
      application of triclosan in mice.
PG  - 165-72
LID - 10.3109/1547691X.2015.1029146 [doi]
AB  - Triclosan is an antimicrobial chemical commonly used occupationally and by the 
      general public. Using select immune function assays, the purpose of these studies 
      was to evaluate the immunotoxicity of triclosan following dermal exposure using a 
      murine model. Triclosan was not identified to be a sensitizer in the murine local 
      lymph node assay (LLNA) when tested at concentrations ranging from 0.75-3.0%. 
      Following a 28-day exposure, triclosan produced a significant increase in liver 
      weight at concentrations of >/= 1.5%. Exposure to the high dose (3.0%) also 
      produced a significant increase in spleen weights and number of platelets. The 
      absolute number of B-cells, T-cells, dendritic cells and NK cells were 
      significantly increased in the skin draining lymph node, but not the spleen. An 
      increase in the frequency of dendritic cells was also observed in the lymph node 
      following exposure to 3.0% triclosan. The IgM antibody response to sheep red 
      blood cells (SRBC) was significantly increased at 0.75% - but not at the higher 
      concentrations - in the spleen and serum. These results demonstrate that dermal 
      exposure to triclosan induces stimulation of the immune system in a murine model 
      and raise concerns about potential human exposure.
FAU - Anderson, Stacey E
AU  - Anderson SE
AD  - a National Institute for Occupational Safety and Health (NIOSH) , Morgantown , WV 
      , USA.
FAU - Meade, B Jean
AU  - Meade BJ
AD  - a National Institute for Occupational Safety and Health (NIOSH) , Morgantown , WV 
      , USA.
FAU - Long, Carrie M
AU  - Long CM
AD  - a National Institute for Occupational Safety and Health (NIOSH) , Morgantown , WV 
      , USA.
FAU - Lukomska, Ewa
AU  - Lukomska E
AD  - a National Institute for Occupational Safety and Health (NIOSH) , Morgantown , WV 
      , USA.
FAU - Marshall, Nikki B
AU  - Marshall NB
AD  - a National Institute for Occupational Safety and Health (NIOSH) , Morgantown , WV 
      , USA.
LA  - eng
GR  - CC999999/Intramural CDC HHS/United States
PT  - Journal Article
DEP - 20150327
PL  - England
TA  - J Immunotoxicol
JT  - Journal of immunotoxicology
JID - 101201960
RN  - 0 (Immunoglobulin M)
RN  - 4NM5039Y5X (Triclosan)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - B-Lymphocytes/*immunology/pathology
MH  - Dendritic Cells/*immunology/pathology
MH  - Female
MH  - Humans
MH  - Immunoglobulin M/immunology
MH  - Killer Cells, Natural/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Spleen/*immunology/pathology
MH  - T-Lymphocytes/*immunology/pathology
MH  - Triclosan/*adverse effects/pharmacology
PMC - PMC4720145
MID - NIHMS749484
OID - NLM: HHSPA749484
OTO - NOTNLM
OT  - Hypersensitivity
OT  - immune suppression
OT  - immunotoxicity
OT  - triclosan
COIS- Declaration of interest The authors report no conflicts of interest. The authors 
      alone are responsible for the content and writing of the paper.
EDAT- 2015/03/31 06:00
MHDA- 2016/10/01 06:00
PMCR- 2016/03/01
CRDT- 2015/03/28 06:00
PHST- 2015/03/28 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2016/10/01 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - 10.3109/1547691X.2015.1029146 [doi]
PST - ppublish
SO  - J Immunotoxicol. 2016;13(2):165-72. doi: 10.3109/1547691X.2015.1029146. Epub 2015 
      Mar 27.