PMID- 25813720
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20150327
IS  - 1879-3592 (Electronic)
IS  - 1383-5718 (Linking)
VI  - 779
DP  - 2015 Feb
TI  - Continuous cytogenetic follow-up, over 5 years, of three individuals accidentally 
      irradiated by a cobalt-60 source.
PG  - 1-4
LID - S1383-5718(15)00032-7 [pii]
LID - 10.1016/j.mrgentox.2015.01.009 [doi]
AB  - A cobalt-60 irradiation accident occurred in Shanxi, China, on April 11, 2008. 
      Five people were exposed to total-body irradiation ranging from 1.7 to 14.5 Gy. 
      Two victims died post-irradiation, due to acute intestinal radiation sickness (at 
      62 days) and tuberculosis (at 1.5 year). The other three victims received medical 
      follow-ups and were monitored for 5 years with multiple cytogenetic analyses. 
      Unstable chromosome aberrations, including dicentric and centric rings (dic+r) 
      and the micronucleus frequency in binucleated lymphocytes, were monitored. In 
      addition, G-banding karyotype and fluorescence in situ hybridization (FISH) 
      methods were used to analyze translocations, for exploring chromosome stability 
      and for retrospective dosimetry. The results show that unstable chromosome 
      aberrations (dic+r) declined each year, dropping to about 20-40% of initial 
      levels by the 5th year. A similar trend was observed for the micronucleus 
      frequency. Our results show that the translocation frequencies of the three 
      victims, detected by G-banding karyotype, remained stable for the 5 years. Five 
      years after irradiation, the translocation rates of the three victims (G-banding 
      and FISH analyses) were similar. The retrospective estimated doses, reconstructed 
      based on the translocation frequencies, were consistent with the biological doses 
      estimated at the first day post-irradiation using dic+r. The results of this 
      study indicate that chromosome translocation frequencies can be used as a 
      biological dosimeter and are an excellent index for dose reconstruction.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Wang, Zhi-Dong
AU  - Wang ZD
AD  - Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
FAU - Zhang, Xue-Qing
AU  - Zhang XQ
AD  - Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
FAU - Du, Jie
AU  - Du J
AD  - Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
FAU - Lu, Xue
AU  - Lu X
AD  - China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, 
      National Institute for Radiological Protection, Chinese Center for Disease 
      Control and Prevention, Beijing 100088, China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
FAU - Tian, Rong
AU  - Tian R
AD  - Affiliated Hospital of China Institute for Radiation Protection, Taiyuan, Shanxi 
      Province 030006, China.
FAU - Liu, Qing-Jie
AU  - Liu QJ
AD  - China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, 
      National Institute for Radiological Protection, Chinese Center for Disease 
      Control and Prevention, Beijing 100088, China. Electronic address: qjliu@nirp.cn.
FAU - Chen, Ying
AU  - Chen Y
AD  - Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China. 
      Electronic address: yingchen_29@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150129
PL  - Netherlands
TA  - Mutat Res Genet Toxicol Environ Mutagen
JT  - Mutation research. Genetic toxicology and environmental mutagenesis
JID - 101632149
RN  - 0 (Cobalt Radioisotopes)
SB  - IM
MH  - Adult
MH  - China
MH  - Chromosome Aberrations/radiation effects
MH  - Chromosome Banding
MH  - Cobalt Radioisotopes/*blood/*toxicity
MH  - Dose-Response Relationship, Radiation
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lymphocytes/radiation effects
MH  - Male
MH  - Radiation Injuries/pathology
MH  - *Radioactive Hazard Release
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - Biological dose
OT  - Chromosomal aberration
OT  - Dose reconstruction
OT  - Follow-up observation
OT  - Radiation accident
EDAT- 2015/03/31 06:00
MHDA- 2015/05/27 06:00
CRDT- 2015/03/28 06:00
PHST- 2014/12/12 00:00 [received]
PHST- 2015/01/26 00:00 [revised]
PHST- 2015/01/28 00:00 [accepted]
PHST- 2015/03/28 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
AID - S1383-5718(15)00032-7 [pii]
AID - 10.1016/j.mrgentox.2015.01.009 [doi]
PST - ppublish
SO  - Mutat Res Genet Toxicol Environ Mutagen. 2015 Feb;779:1-4. doi: 
      10.1016/j.mrgentox.2015.01.009. Epub 2015 Jan 29.