PMID- 25814534
OWN - NLM
STAT- MEDLINE
DCOM- 20160720
LR  - 20151010
IS  - 1753-9455 (Electronic)
IS  - 1753-9447 (Linking)
VI  - 9
IP  - 5
DP  - 2015 Oct
TI  - Value of pentraxin-3 and galectin-3 in acute coronary syndrome: a short-term 
      prospective cohort study.
PG  - 275-84
LID - 10.1177/1753944715578405 [doi]
AB  - BACKGROUND: Acute coronary syndrome (ACS) continues to be a leading cause of 
      morbidity and mortality worldwide. Galectin-3 and pentraxin-3 are two prognostic 
      biomarkers that have been studied in heart failure (HF). However, there are 
      limited data on these biomarkers in the ACS population. The objective of the 
      study was to determine the variables that are most affected by high 
      concentrations of pentraxin-3 and galectin-3, and the influence they have on 
      outcomes of all-cause mortality in patients with ACS. METHODS: We included a 
      total of 160 patients [ST elevation myocardial infarction (STEMI),n = 64; non 
      STEMI/unstable angina (NSTEMI/UA), n = 38; and control subjects with chronic 
      stable angina (CSA)/microvascular angina (MVA) n = 58]. Plasma pentraxin-3 and 
      galectin-3 levels were assessed from these patients at the time of hospital 
      admission. Major adverse cardiovascular events including all-cause mortality, 
      rehospitalizations and coronary artery bypass graft surgery (CABG) were assessed 
      at 6 months. RESULTS: The median concentration of pentraxin-3 and galectin-3 were 
      significantly higher in STEMI than in NSTEMI patients (p < 0.005) or controls (p 
      < 0.005). Greater numbers of deaths (4 versus 0) were observed in STEMI patients 
      with higher levels of these biomarkers. In addition, ACS patients with high 
      levels of pentraxin-3 and galectin-3 had lower left ventricular ejection fraction 
      (LVEF) (p < 0.005), and a moderate correlation was observed between LVEF and 
      pentraxin-3 levels (r = -0.45, p < 0.005). Patients with higher galectin-3 levels 
      were also observed to have a lower estimated glomerular fraction rate (eGFR), and 
      a moderate correlation was observed between them (r = -0.34, p < 0.005). 
      CONCLUSION: Pentraxin-3 and galectin-3 hold much promise in the ACS population as 
      prognostic biomarkers.
CI  - (c) The Author(s), 2015.
FAU - George, Melvin
AU  - George M
AD  - Department of Cardiology, SRM Medical College Hospital & Research Centre, 
      Kattankulathur, Kancheepuram, Chennai, Tamil Nadu 603203, India 
      melvingeorge2003@gmail.com.
FAU - Shanmugam, Elangovan
AU  - Shanmugam E
AD  - Department of Cardiology, SRM Medical College Hospital & Research Centre, 
      Chennai, India.
FAU - Srivatsan, Varsha
AU  - Srivatsan V
AD  - Department of Cardiology, SRM Medical College Hospital & Research Centre, 
      Chennai, India.
FAU - Vasanth, Karunamoorthy
AU  - Vasanth K
AD  - ISISM, SRM University, Chennai, India.
FAU - Ramraj, Balaji
AU  - Ramraj B
AD  - Department of Community Medicine, SRM Medical College Hospital & Research Centre, 
      Chennai, India.
FAU - Rajaram, Muthukumar
AU  - Rajaram M
AD  - Department of Cardiology, SRM Medical College Hospital & Research Centre, 
      Chennai, India.
FAU - Jena, Amrita
AU  - Jena A
AD  - Department of Cardiology, SRM Medical College Hospital & Research Centre, 
      Chennai, India.
FAU - Sridhar, Aruna
AU  - Sridhar A
AD  - Department of Cardiology, SRM Medical College Hospital & Research Centre, 
      Chennai, India.
FAU - Chaudhury, Minakshi
AU  - Chaudhury M
AD  - ISISM, SRM University, Chennai, India.
FAU - Kaliappan, Ilango
AU  - Kaliappan I
AD  - ISISM, SRM University, Chennai, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150325
PL  - England
TA  - Ther Adv Cardiovasc Dis
JT  - Therapeutic advances in cardiovascular disease
JID - 101316343
RN  - 0 (Biomarkers)
RN  - 0 (Galectin 3)
RN  - 0 (Serum Amyloid P-Component)
RN  - 148591-49-5 (PTX3 protein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute Coronary Syndrome/blood/mortality/*physiopathology
MH  - Adult
MH  - Angina, Unstable/blood/mortality/physiopathology
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Cohort Studies
MH  - Female
MH  - Galectin 3/*blood
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/mortality/*physiopathology
MH  - Prognosis
MH  - Prospective Studies
MH  - Serum Amyloid P-Component/*metabolism
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - acute coronary syndrome
OT  - all-cause mortality
OT  - estimated glomerular filtration rate
OT  - galectin-3
OT  - left ventricular ejection fraction
OT  - pentraxin-3
EDAT- 2015/03/31 06:00
MHDA- 2016/07/21 06:00
CRDT- 2015/03/28 06:00
PHST- 2015/03/28 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2016/07/21 06:00 [medline]
AID - 1753944715578405 [pii]
AID - 10.1177/1753944715578405 [doi]
PST - ppublish
SO  - Ther Adv Cardiovasc Dis. 2015 Oct;9(5):275-84. doi: 10.1177/1753944715578405. 
      Epub 2015 Mar 25.