PMID- 25814751
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150327
LR  - 20181113
IS  - 1998-3611 (Electronic)
IS  - 0019-5154 (Print)
IS  - 0019-5154 (Linking)
VI  - 60
IP  - 2
DP  - 2015 Mar-Apr
TI  - Ulceronecrotic penicillosis.
PG  - 215
LID - 10.4103/0019-5154.152607 [doi]
AB  - A 40-year-old male human immunodeficiency virus (HIV) -positive patient on highly 
      active antiretroviral therapy (HAART) developed bilateral cervical 
      lymphadenopathy with fine needle aspiration cytology (FNAC) showing yeast cells 
      of Penicillium marneffei. The adenopathy disappeared after 9 months of 
      itraconazole therapy at a dose of 200 mg/day. Seven years later and 2 days 
      following second-line HAART, the patient presented with generalized papulonodules 
      and ulceronecrotic lesions. Biopsy of the skin lesion revealed plenty of yeast 
      forms dividing by binary fission morphologically resembling Penicillium 
      marneffei. Significant improvement was observed at 2 weeks of starting 
      itraconazole 400 mg/day. After 3 months, the dose was reduced to 200 mg/day and 
      advised to continue for 6 months. Penicillosis presenting initially in the form 
      of cervical adenopathy and later, developing typical skin lesions rapidly 
      progressing to ulcerative and necrotic erosions may be due to continued 
      immunosuppression followed by immune reconstitution inflammatory syndrome (IRIS).
FAU - Bachaspatimayum, Romita
AU  - Bachaspatimayum R
AD  - Department of Dermatology, Venereology and Leprology, Regional Institute of 
      Medical Science, Imphal, Manipur, India.
FAU - Haokip, Thangjamang
AU  - Haokip T
AD  - Department of Dermatology, Venereology and Leprology, Regional Institute of 
      Medical Science, Imphal, Manipur, India.
FAU - Zamzachin, G
AU  - Zamzachin G
AD  - Department of Dermatology, Venereology and Leprology, Regional Institute of 
      Medical Science, Imphal, Manipur, India.
FAU - Devi, Yanglem Elizabeth
AU  - Devi YE
AD  - Department of Dermatology, Venereology and Leprology, Regional Institute of 
      Medical Science, Imphal, Manipur, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Dermatol
JT  - Indian journal of dermatology
JID - 0370750
PMC - PMC4372955
OTO - NOTNLM
OT  - Highly active antiretroviral therapy
OT  - immune reconstitution inflammatory syndrome penicillium marneffei
OT  - relapse
OT  - ulceronecrotic
COIS- Conflict of Interest: Nil.
EDAT- 2015/03/31 06:00
MHDA- 2015/03/31 06:01
PMCR- 2015/03/01
CRDT- 2015/03/28 06:00
PHST- 2015/03/28 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2015/03/31 06:01 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - IJD-60-215f [pii]
AID - 10.4103/0019-5154.152607 [doi]
PST - ppublish
SO  - Indian J Dermatol. 2015 Mar-Apr;60(2):215. doi: 10.4103/0019-5154.152607.