PMID- 25816123
OWN - NLM
STAT- MEDLINE
DCOM- 20160517
LR  - 20181113
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 123
IP  - 8
DP  - 2015 Aug
TI  - In Utero Fine Particle Air Pollution and Placental Expression of Genes in the 
      Brain-Derived Neurotrophic Factor Signaling Pathway: An ENVIRONAGE Birth Cohort 
      Study.
PG  - 834-40
LID - 10.1289/ehp.1408549 [doi]
AB  - BACKGROUND: Developmental processes in the placenta and the fetal brain are 
      shaped by the same biological signals. Recent evidence suggests that adaptive 
      responses of the placenta to the maternal environment may influence central 
      nervous system development. OBJECTIVES: We studied the association between in 
      utero exposure to fine particle air pollution with a diameter </= 2.5 mum (PM2.5) 
      and placental expression of genes implicated in neural development. METHODS: 
      Expression of 10 target genes in the brain-derived neurotrophic factor (BDNF) 
      signaling pathway were quantified in placental tissue of 90 mother-infant pairs 
      from the ENVIRONAGE birth cohort using quantitative real-time polymerase chain 
      reaction. Trimester-specific PM2.5 exposure levels were estimated for each 
      mother's home address using a spatiotemporal model. Mixed-effects models were 
      used to evaluate the association between the target genes and PM2.5 exposure 
      measured in different time windows of pregnancy. RESULTS: A 5-mug/m3 increase in 
      residential PM2.5 exposure during the first trimester of pregnancy was associated 
      with a 15.9% decrease [95% confidence interval (CI): -28.7, -3.2%, p = 0.015] in 
      expression of placental BDNF at birth. The corresponding estimate for synapsin 1 
      (SYN1) was a 24.3% decrease (95% CI: -42.8, -5.8%, p = 0.011). CONCLUSIONS: 
      Placental expression of BDNF and SYN1, two genes implicated in normal 
      neurodevelopmental trajectories, decreased with increasing in utero exposure to 
      PM2.5. Future studies are needed to confirm our findings and evaluate the 
      potential relevance of associations between PM2.5 and placental expression of 
      BDNF and SYN1 on neurodevelopment. We provide the first molecular epidemiological 
      evidence concerning associations between in utero fine particle air pollution 
      exposure and the expression of genes that may influence neurodevelopmental 
      processes.
FAU - Saenen, Nelly D
AU  - Saenen ND
AD  - Centre for Environmental Sciences, Hasselt University, Diepenbeek, Limburg, 
      Belgium.
FAU - Plusquin, Michelle
AU  - Plusquin M
FAU - Bijnens, Esmee
AU  - Bijnens E
FAU - Janssen, Bram G
AU  - Janssen BG
FAU - Gyselaers, Wilfried
AU  - Gyselaers W
FAU - Cox, Bianca
AU  - Cox B
FAU - Fierens, Frans
AU  - Fierens F
FAU - Molenberghs, Geert
AU  - Molenberghs G
FAU - Penders, Joris
AU  - Penders J
FAU - Vrijens, Karen
AU  - Vrijens K
FAU - De Boever, Patrick
AU  - De Boever P
FAU - Nawrot, Tim S
AU  - Nawrot TS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150327
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Air Pollutants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Particulate Matter)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Air Pollutants/*analysis
MH  - Belgium
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Cohort Studies
MH  - *Environmental Exposure
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Particle Size
MH  - Particulate Matter/*analysis
MH  - Placenta/*drug effects/metabolism
MH  - Pregnancy
MH  - Pregnancy Trimesters
MH  - Real-Time Polymerase Chain Reaction
MH  - Signal Transduction/*drug effects
MH  - Young Adult
PMC - PMC4529006
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2015/03/31 06:00
MHDA- 2016/05/18 06:00
PMCR- 2015/08/01
CRDT- 2015/03/28 06:00
PHST- 2014/04/11 00:00 [received]
PHST- 2015/03/24 00:00 [accepted]
PHST- 2015/03/28 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - ehp.1408549 [pii]
AID - 10.1289/ehp.1408549 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2015 Aug;123(8):834-40. doi: 10.1289/ehp.1408549. Epub 
      2015 Mar 27.