PMID- 25816395
OWN - NLM
STAT- MEDLINE
DCOM- 20170404
LR  - 20170404
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 28
IP  - 2
DP  - 2015 Jun
TI  - Synthesis, characterization, and efficacy evaluation of a new anti-diabetic 
      vanadyl(II) thiamine hydrochloride complex in streptozotocin-induced diabetic 
      rats.
PG  - 227-39
LID - 10.1177/0394632015576036 [doi]
AB  - Diabetes mellitus (DM) is a chronic metabolic disorder characterized by 
      hyperglycemia due to abnormalities in either insulin secretion or action. A range 
      of vanadium complexes have been synthesized and demonstrated to be effective in 
      lowering hyperglycemia. Thiamine administration was also reported to prevent 
      deterioration in fasting glucose and insulin levels, and to improve glucose 
      tolerance in hyperglycemic patients. This study has been conducted to evaluate 
      the ionic vanadyl(II) thiamine hydrochloride complex (VC) as a new anti-diabetic 
      candidate. The new complex was characterized by infrared spectroscopy (FT-IR), 
      electronic spectra, magnetic susceptibility, electron spin resonance (ESR), 
      scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The 
      anti-diabetic effect of VC was investigated in comparison to vanadium sulfate in 
      streptozotocin (STZ)-induced diabetic rats. Treatment of diabetic rats with VC 
      versus vanadyl sulfate showed a more potent effect on reducing serum glucose and 
      cholesterol close to normal levels. VC suppressed the diabetes-induced 
      upregulation of hepatic glucose transporter (GLUT)-2, Phosphoenol pyruvate 
      carboxykinase (PEPCK), and hormone-sensitive lipase (HSL) more significantly than 
      vanadyl sulfate. Either vanadyl sulfate or VC restored hepatic sterol regulatory 
      element-binding protein transcription factor-1c (SREBP-1c) and muscle hexokinase 
      (HK) mRNA expression that was downregulated in diabetic group. Pyruvate kinase 
      (PK) mRNA expression was restored more significantly in VC-treated than vanadyl 
      sulfate-treated diabetic rats. These results indicate that the newly synthesized 
      VC could be an effective anti-diabetic candidate as the anti-diabetic activity of 
      the ionic vanadium was enhanced after being modified with the organic ligand, 
      thiamin. The results also suggest that VC achieves its effect most likely through 
      modulating the transcription of energy metabolizing enzymes.
CI  - (c) The Author(s) 2015.
FAU - Ahmed El-Shazly, Samir
AU  - Ahmed El-Shazly S
AD  - Department of Biotechnology, College of Science, Taif University, Saudi Arabia 
      Department of Biochemistry, Faculty of Veterinary Medicine, Kaferelsheikh 
      University, Egypt.
FAU - Ahmed, Mohamed Mohamed
AU  - Ahmed MM
AD  - Department of Biotechnology, College of Science, Taif University, Saudi Arabia 
      Department of Biochemistry, Faculty of Veterinary Medicine, University of Sadat 
      City, Egypt m_m_ahmed@yahoo.com.
FAU - Ibrahim, Zein Shaban
AU  - Ibrahim ZS
AD  - Department of Physiology, Faculty of Veterinary Medicine, Kaferelsheikh 
      University, Egypt Department of Physiology, Faculty of Medicine, Taif University, 
      Saudi Arabia.
FAU - Refat, Moamen S
AU  - Refat MS
AD  - Department of Chemistry, College of Science, Taif University, Saudi Arabia 
      Department of Chemistry, Faculty of Science, Port Said University, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20150326
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Vanadium Compounds)
RN  - 5W494URQ81 (Streptozocin)
RN  - 6DU9Y533FA (vanadyl sulfate)
RN  - X66NSO3N35 (Thiamine)
SB  - IM
MH  - Animals
MH  - Blood Glucose/drug effects
MH  - Diabetes Mellitus, Experimental/*chemically induced/*drug therapy
MH  - Hypoglycemic Agents/*pharmacology
MH  - Insulin/metabolism
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Streptozocin/*pharmacology
MH  - Thiamine/*pharmacology
MH  - Vanadium Compounds/*pharmacology
OTO - NOTNLM
OT  - STZ-induced diabetes
OT  - gene expression
OT  - thiamine
OT  - vanadium
EDAT- 2015/03/31 06:00
MHDA- 2017/04/05 06:00
CRDT- 2015/03/28 06:00
PHST- 2014/12/13 00:00 [received]
PHST- 2015/02/13 00:00 [accepted]
PHST- 2015/03/28 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2017/04/05 06:00 [medline]
AID - 0394632015576036 [pii]
AID - 10.1177/0394632015576036 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2015 Jun;28(2):227-39. doi: 
      10.1177/0394632015576036. Epub 2015 Mar 26.