PMID- 25816734
OWN - NLM
STAT- MEDLINE
DCOM- 20160106
LR  - 20180813
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 25
IP  - 5
DP  - 2015 May
TI  - Lower bone turnover markers in metabolic syndrome and diabetes: the 
      population-based Study of Health in Pomerania.
PG  - 458-63
LID - S0939-4753(15)00033-2 [pii]
LID - 10.1016/j.numecd.2015.02.002 [doi]
AB  - BACKGROUND AND AIMS: Accumulating evidence demonstrates an important interaction 
      between bone and energy metabolism. We aimed to study the associations of three 
      bone turnover markers (BTM: osteocalcin, beta-crosslaps, procollagen type 
      1 N-terminal propeptide) as well as of 25-hydroxyvitamin D and parathyroid 
      hormone with metabolic syndrome (MetS) or type 2 diabetes mellitus (T2DM) in a 
      large population-based cohort. METHODS AND RESULTS: This cross-sectional study 
      comprised 2671 adult men and women participating in the first follow-up of the 
      population-based Study of Health in Pomerania (SHIP-1). Multivariable logistic 
      regression analyses were performed to assess sex-specific associations between 
      the BTMs, 25-hydroxyvitamin D or parathyroid hormone and metabolic disease. All 
      models were adjusted for age, body mass index, smoking status, physical activity, 
      estimated glomerular filtration rate and month of blood sampling. The models for 
      women were further adjusted for menopausal status. Higher BTM or 
      25-hydroxyvitamin D concentrations were associated with significantly lower odds 
      for metabolic disease, while there was no association between parathyroid hormone 
      and MetS or T2DM. CONCLUSION: Our results contribute to the accumulating evidence 
      of a cross-sectional association between high BTM or 25-hydroxyvitamin D 
      concentrations and a lower prevalence of MetS or T2DM. Further research is 
      necessary to evaluate the mechanisms underlying these results.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Lerchbaum, E
AU  - Lerchbaum E
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism, 
      Medical University of Graz, Austria; University Women's Hospital, Heidelberg, 
      Germany.
FAU - Schwetz, V
AU  - Schwetz V
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism, 
      Medical University of Graz, Austria.
FAU - Nauck, M
AU  - Nauck M
AD  - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine 
      Greifswald, Germany.
FAU - Volzke, H
AU  - Volzke H
AD  - Institute for Community Medicine, University Medicine Greifswald, Germany.
FAU - Wallaschofski, H
AU  - Wallaschofski H
AD  - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine 
      Greifswald, Germany.
FAU - Hannemann, A
AU  - Hannemann A
AD  - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine 
      Greifswald, Germany. Electronic address: anke.hannemann@uni-greifswald.de.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150212
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Biomarkers)
RN  - 0 (PTH protein, human)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Peptide Fragments)
RN  - 0 (Procollagen)
RN  - 0 (glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine)
RN  - 0 (procollagen type I carboxy terminal peptide)
RN  - 104982-03-8 (Osteocalcin)
RN  - 1406-16-2 (Vitamin D)
RN  - 9007-34-5 (Collagen)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - *Bone Remodeling
MH  - Cohort Studies
MH  - Collagen/*blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/*metabolism
MH  - *Down-Regulation
MH  - Female
MH  - Follow-Up Studies
MH  - Germany/epidemiology
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/blood/epidemiology/*metabolism
MH  - Middle Aged
MH  - Osteocalcin/*blood
MH  - Parathyroid Hormone/blood
MH  - Peptide Fragments/*blood
MH  - Prevalence
MH  - Procollagen/*blood
MH  - Vitamin D/analogs & derivatives/blood
MH  - Young Adult
OTO - NOTNLM
OT  - 25-hydroxyvitamin D
OT  - Beta-crosslaps
OT  - Osteocalcin
OT  - Procollagen type 1 N-terminal propeptide
EDAT- 2015/03/31 06:00
MHDA- 2016/01/07 06:00
CRDT- 2015/03/31 06:00
PHST- 2014/08/15 00:00 [received]
PHST- 2015/01/29 00:00 [revised]
PHST- 2015/02/01 00:00 [accepted]
PHST- 2015/03/31 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2016/01/07 06:00 [medline]
AID - S0939-4753(15)00033-2 [pii]
AID - 10.1016/j.numecd.2015.02.002 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2015 May;25(5):458-63. doi: 
      10.1016/j.numecd.2015.02.002. Epub 2015 Feb 12.