PMID- 25817235
OWN - NLM
STAT- MEDLINE
DCOM- 20150717
LR  - 20150828
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 130
DP  - 2015 Jun 1
TI  - Prenatal zinc prevents communication impairments and BDNF disturbance in a rat 
      model of autism induced by prenatal lipopolysaccharide exposure.
PG  - 12-7
LID - S0024-3205(15)00164-2 [pii]
LID - 10.1016/j.lfs.2015.02.027 [doi]
AB  - Aims: Previous investigations by our group have shown that prenatal exposure to 
      lipopolysaccharide (LPS),which mimics infections by Gram-negative bacteria, 
      induced autistic-like behavior. No effective treatment yet exists for autism. 
      Therefore, we used our rat model to test a possible treatment for autism.We 
      selected zinc as the prenatal treatment to prevent or ease the impairments 
      induced by LPS because LPS induces hypozincaemia.Materials and methods:We 
      evaluated the effects of LPS and zinc on female reproductive performance. 
      Communication,which is impaired in autism,was tested in pups by ultrasonic 
      vocalizations. Plasma levels of brain-derived neurotrophic factor (BDNF) were 
      determined because it has been considered an autism important biomarker.Key 
      findings: Prenatal LPS exposure reduced offspring number and treatment with zinc 
      prevented this reduction.Moreover, pups that were prenatally exposed to LPS spent 
      longer periods without calling their mothers, and posttreatment with zinc 
      prevented this impairment induced by LPS to the same levels as controls. Prenatal 
      LPS also increased BDNF levels in adult offspring, and posttreatment with zinc 
      reduced the elevation of BDNF to the same levels as controls.Significance: BDNF 
      hyperactivity was also found in several studies of autistic patients. Together 
      with our previous studies, our model of prenatal LPS induced autistic-like 
      behavioral, brain, and immune disturbances. This suggests that it is a valid rat 
      model of autism. Prenatal zinc prevented reproductive, communication, and BDNF 
      impairments.The present study revealed a potential beneficial effect of prenatal 
      zinc administration for the prevention of autism with regard to the BDNF pathway.
FAU - Kirsten, Thiago B
AU  - Kirsten TB
AD  - Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, 
      Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo, SP 05508-270, Brazil; 
      Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 
      1212, Sao Paulo, SP 04026-002, Brazil. Electronic address: thik@outlook.com.
FAU - Queiroz-Hazarbassanov, Nicolle
AU  - Queiroz-Hazarbassanov N
AD  - Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, 
      Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo, SP 05508-270, Brazil.
FAU - Bernardi, Maria M
AU  - Bernardi MM
AD  - Environmental and Experimental Pathology, Paulista University, Rua Dr. Bacelar, 
      1212, Sao Paulo, SP 04026-002, Brazil.
FAU - Felicio, Luciano F
AU  - Felicio LF
AD  - Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, 
      Av. Prof. Dr. Orlando Marques de Paiva, 87, Sao Paulo, SP 05508-270, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150325
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipopolysaccharides)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Autistic Disorder/physiopathology/*prevention & control
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - *Communication
MH  - Disease Models, Animal
MH  - Female
MH  - Lipopolysaccharides/toxicity
MH  - Male
MH  - Maternal Exposure
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Vocalization, Animal
MH  - Zinc/*administration & dosage/pharmacology
OTO - NOTNLM
OT  - Autistic-like effects
OT  - Gestation
OT  - Maternal immune activation
OT  - Prenatal infection
OT  - Ultrasonic vocalizations
EDAT- 2015/03/31 06:00
MHDA- 2015/07/18 06:00
CRDT- 2015/03/31 06:00
PHST- 2014/10/22 00:00 [received]
PHST- 2015/02/11 00:00 [revised]
PHST- 2015/02/26 00:00 [accepted]
PHST- 2015/03/31 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2015/07/18 06:00 [medline]
AID - S0024-3205(15)00164-2 [pii]
AID - 10.1016/j.lfs.2015.02.027 [doi]
PST - ppublish
SO  - Life Sci. 2015 Jun 1;130:12-7. doi: 10.1016/j.lfs.2015.02.027. Epub 2015 Mar 25.