PMID- 25817279
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1349-6867 (Electronic)
IS  - 1343-1420 (Linking)
VI  - 62
IP  - 1-2
DP  - 2015
TI  - Recent progress in the development of genetically encoded Ca2+ indicators.
PG  - 24-8
LID - 10.2152/jmi.62.24 [doi]
AB  - Genetically encoded calcium indicators (GECIs) are powerful tools to monitor the 
      dynamics of calcium ion (Ca(2+)) in living cells and organisms. With the help of 
      GFP technology and DNA engineering, a dozen sets of GECIs have been developed so 
      far. Their application has been widely extended into the analysis at the 
      subcellular local, single and population of cell. In the past decades, GECIs have 
      been dramatically improved in their performance and are becoming more and more 
      useful for live imaging. In this review, the progress in the development of GECIs 
      is discussed by introducing the history and emerging GECIs, which would help the 
      selection of the appropriate GECI for a given application.
FAU - Horikawa, Kazuki
AU  - Horikawa K
AD  - Division for Bio-imaging, Support Center for Advanced Medical Sciences, Institute 
      of Health Biosciences, the University of Tokushima Graduate School.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - J Med Invest
JT  - The journal of medical investigation : JMI
JID - 9716841
RN  - 0 (Indicators and Reagents)
RN  - 0 (Luminescent Proteins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/*metabolism
MH  - Calcium Signaling
MH  - Fluorescence Resonance Energy Transfer
MH  - Humans
MH  - Indicators and Reagents
MH  - Luminescent Proteins/genetics/metabolism
MH  - Neurons/metabolism
MH  - Optogenetics
MH  - Protein Engineering/trends
EDAT- 2015/03/31 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/03/31 06:00
PHST- 2015/03/31 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.2152/jmi.62.24 [doi]
PST - ppublish
SO  - J Med Invest. 2015;62(1-2):24-8. doi: 10.2152/jmi.62.24.