PMID- 25817699
OWN - NLM
STAT- MEDLINE
DCOM- 20150930
LR  - 20221207
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 181
IP  - 2
DP  - 2015 Aug
TI  - Positive association between serum thymic stromal lymphopoietin and 
      anti-citrullinated peptide antibodies in patients with rheumatoid arthritis.
PG  - 239-43
LID - 10.1111/cei.12632 [doi]
AB  - Thymic stromal lymphopoietin (TSLP) has been suggested recently to play an 
      important role in the pathophysiology of rheumatoid arthritis (RA). However, 
      there is little information on serum TSLP concentrations in RA and its clinical 
      significance. The present study investigated whether serum TSLP concentrations 
      were affected in patients with RA. Using an enzyme-linked immunosorbent assay 
      (ELISA), we measured TSLP concentrations in the serum obtained from 100 patients 
      with RA, 60 patients with osteoarthritis (OA) and 34 healthy volunteers. We also 
      investigated the correlation between serum TSLP concentrations and clinical 
      parameters of disease activity in RA [disease activity score using 28 joint 
      counts (DAS28)-C-reactive protein (CRP), DAS28-erythrocyte sedimentation rate 
      (ESR), Clinical Disease Activity Index (CDAI]), patient's/-physician's Visual 
      Analogue Scale (VAS), swollen joints count, tender joints count, CRP, ESR and 
      matrix metalloproteinase-3 (MMP-3) concentrations]. In addition, we investigated 
      the correlation between serum TSLP concentrations and anti-citrullinated peptide 
      antibody (ACPA) and serum tumour necrosis factor (TNF)-alpha. Serum TSLP levels in 
      patients with RA were significantly higher than those in patients with OA and in 
      healthy volunteers. Interestingly, serum TSLP concentrations were correlated 
      significantly with ACPA titres, but not with other clinical parameters. There was 
      a significant increase in serum TSLP concentrations in patients with RA, which 
      was correlated positively with serum ACPA titres. These findings suggest that in 
      patients with RA, TSLP may play a role in ACPA production by B cells.
CI  - (c) 2015 British Society for Immunology.
FAU - Koyama, K
AU  - Koyama K
AD  - Department of Orthopaedic Surgery.
FAU - Ohba, T
AU  - Ohba T
AD  - Department of Orthopaedic Surgery.
FAU - Haro, H
AU  - Haro H
AD  - Department of Orthopaedic Surgery.
FAU - Nakao, A
AU  - Nakao A
AD  - Department of Immunology, Faculty of Medicine, University of Yamanashi, 
      Yamanashi, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Autoantibodies)
RN  - 0 (Cytokines)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (cyclic citrullinated peptide)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthritis, Rheumatoid/blood/*immunology/pathology
MH  - Autoantibodies/*blood
MH  - B-Lymphocytes/immunology/metabolism/pathology
MH  - Blood Sedimentation
MH  - C-Reactive Protein/immunology/metabolism
MH  - Case-Control Studies
MH  - Cytokines/blood/genetics/*immunology
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Joints/immunology/metabolism/pathology
MH  - Male
MH  - Matrix Metalloproteinase 3/blood/genetics/immunology
MH  - Middle Aged
MH  - Osteoarthritis/blood/*immunology/pathology
MH  - Peptides, Cyclic/blood/immunology
MH  - Severity of Illness Index
MH  - Signal Transduction
MH  - Tumor Necrosis Factor-alpha/blood/genetics/immunology
MH  - Thymic Stromal Lymphopoietin
PMC - PMC4516439
OTO - NOTNLM
OT  - ACPA
OT  - rheumatoid arthritis
OT  - serum
OT  - thymic stromal lymphopoietin
EDAT- 2015/03/31 06:00
MHDA- 2015/10/01 06:00
PMCR- 2016/08/01
CRDT- 2015/03/31 06:00
PHST- 2015/01/05 00:00 [received]
PHST- 2015/03/18 00:00 [revised]
PHST- 2015/03/23 00:00 [accepted]
PHST- 2015/03/31 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2015/10/01 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - 10.1111/cei.12632 [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2015 Aug;181(2):239-43. doi: 10.1111/cei.12632.