PMID- 25819020
OWN - NLM
STAT- MEDLINE
DCOM- 20151223
LR  - 20220330
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 50
IP  - 6
DP  - 2015 Jun
TI  - Pediatric papillary thyroid cancer >1 cm: is total thyroidectomy necessary?
PG  - 1009-13
LID - S0022-3468(15)00202-X [pii]
LID - 10.1016/j.jpedsurg.2015.03.031 [doi]
AB  - PURPOSE: Treatment of pediatric papillary thyroid cancer (p-PTC) often follows 
      adult guidelines, including total thyroidectomy for tumors >1cm. This study 
      examined the association between operation type and overall survival (OS) for 
      tumors >1cm in size in the pediatric population. METHODS: Patients </= 21 years of 
      age with primary papillary thyroid cancer >1cm were reviewed from the National 
      Cancer Data Base (NCDB) from 1998 to 2011. Kaplan-Meier analysis followed by Cox 
      proportional hazard models estimated the impact of total thyroidectomy (TT) vs. 
      partial thyroidectomy (PT) on overall survival. Models were adjusted for patient, 
      tumor, and treatment factors. RESULTS: 3,861 cases (3474 TT, 387 PT) were 
      included. Estimated 15-year overall survival was 96.10% after TT and 96.18% after 
      PT (p=0.0855). In multivariate analysis of 3173 patients, only lowest 
      socioeconomic level (HR 4.93, p=0.001) and unfavorable histology (HR 6.11, 
      p=0.016) were associated with worse OS. Survival for patients undergoing TT was 
      not statistically improved over those undergoing PT (HR 0.81, p=0.694). 
      CONCLUSION: p-PTC >1cm has an excellent 15-year overall survival. Treatment with 
      TT did not have an improved OS compared to PT. Lower socioeconomic status and 
      unfavorable histology were associated with decreased OS.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Nice, Tate
AU  - Nice T
AD  - Department of Surgery, Division of Pediatric Surgery, University of Alabama at 
      Birmingham, Children's Hospital of Alabama, Birmingham, AL. Electronic address: 
      Tate.Nice@childrensal.org.
FAU - Pasara, Sebastian
AU  - Pasara S
AD  - School of Public Health, University of Alabama at Birmingham, Birmingham, AL.
FAU - Goldfarb, Melanie
AU  - Goldfarb M
AD  - Department of Surgery, John Wayne Cancer Institute/Providence St. John's Medical 
      Center, Santa Monica, CA.
FAU - Doski, John
AU  - Doski J
AD  - Department of Surgery/Pediatric Surgery Division, University of Texas Health 
      Science Center, San Rosa Children's Hospital, San Antonio, TX.
FAU - Goldin, Adam
AU  - Goldin A
AD  - Division of General and Thoracic Surgery, Seattle Children's Hospital, Seattle, 
      WA.
FAU - Gow, Kenneth W
AU  - Gow KW
AD  - Division of General and Thoracic Surgery, Seattle Children's Hospital, Seattle, 
      WA.
FAU - Nuchtern, Jed G
AU  - Nuchtern JG
AD  - Division of Pediatric Surgery, Baylor College of Medicine, Houston, TX.
FAU - Vasudevan, Sanjeev A
AU  - Vasudevan SA
AD  - Division of Pediatric Surgery, Baylor College of Medicine, Houston, TX.
FAU - Langer, Monica
AU  - Langer M
AD  - Division of Pediatric Surgery, Maine Medical Center, Portland, ME.
FAU - Beierle, Elizabeth A
AU  - Beierle EA
AD  - Department of Surgery, Division of Pediatric Surgery, University of Alabama at 
      Birmingham, Children's Hospital of Alabama, Birmingham, AL.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20150314
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Adolescent
MH  - Carcinoma/mortality/pathology/*surgery
MH  - Carcinoma, Papillary
MH  - Child
MH  - Child, Preschool
MH  - Databases, Factual
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Multivariate Analysis
MH  - Proportional Hazards Models
MH  - Thyroid Cancer, Papillary
MH  - Thyroid Neoplasms/mortality/pathology/*surgery
MH  - Thyroidectomy/*methods
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Papillary thyroid cancer
OT  - Pediatric
OT  - Thyroidectomy
EDAT- 2015/03/31 06:00
MHDA- 2015/12/24 06:00
CRDT- 2015/03/31 06:00
PHST- 2015/02/26 00:00 [received]
PHST- 2015/03/10 00:00 [accepted]
PHST- 2015/03/31 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2015/12/24 06:00 [medline]
AID - S0022-3468(15)00202-X [pii]
AID - 10.1016/j.jpedsurg.2015.03.031 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2015 Jun;50(6):1009-13. doi: 10.1016/j.jpedsurg.2015.03.031. Epub 
      2015 Mar 14.