PMID- 25819347
OWN - NLM
STAT- MEDLINE
DCOM- 20151016
LR  - 20230717
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 232
IP  - 2
DP  - 2015 May 30
TI  - A splitting brain: Imbalanced neural networks in schizophrenia.
PG  - 145-53
LID - S0925-4927(15)00061-X [pii]
LID - 10.1016/j.pscychresns.2015.03.001 [doi]
AB  - Dysconnectivity between key brain systems has been hypothesized to underlie the 
      pathophysiology of schizophrenia. The present study examined the pattern of 
      functional dysconnectivity across whole-brain neural networks in 121 
      first-episode, treatment-naive patients with schizophrenia by using resting-state 
      functional magnetic resonance imaging (rsfMRI). Group independent component 
      analysis (ICA) was first applied to rsfMRI data to extract 90 functional 
      components of the brain. The functional connectivity between these ICA components 
      was then evaluated and compared between the patient and control groups. To 
      examine the functional roles of significantly altered between-component 
      connections in patients, each ICA component was ascribed to one of 10 previously 
      well-defined brain networks/areas. Relative to findings in healthy controls 
      (n=103), 29 altered functional connections including 19 connections with 
      increased connectivity and 10 connections with decreased connectivity in 
      schizophrenia patients were found. Increased connectivity was mainly within the 
      default mode network (DMN) and between the DMN and cognitive networks, whereas 
      decreased connectivity was predominantly associated with sensory networks. Given 
      the key roles of the DMN in internal mental processes and sensory networks in 
      inputs from the external environment, these patterns of altered brain network 
      connectivity could suggest imbalanced neural processing of internal and external 
      information in schizophrenia.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Li, Mingli
AU  - Li M
AD  - The Mental Health Center and the Psychiatric Laboratory, West China Hospital, 
      Sichuan University, Chengdu, Sichuan, China; State Key Laboratory of Biotherapy, 
      West China Hospital, Sichuan University, Chengdu, Sichuan, China.
FAU - Deng, Wei
AU  - Deng W
AD  - The Mental Health Center and the Psychiatric Laboratory, West China Hospital, 
      Sichuan University, Chengdu, Sichuan, China; State Key Laboratory of Biotherapy, 
      West China Hospital, Sichuan University, Chengdu, Sichuan, China.
FAU - He, Zongling
AU  - He Z
AD  - The Mental Health Center and the Psychiatric Laboratory, West China Hospital, 
      Sichuan University, Chengdu, Sichuan, China; State Key Laboratory of Biotherapy, 
      West China Hospital, Sichuan University, Chengdu, Sichuan, China.
FAU - Wang, Qiang
AU  - Wang Q
AD  - The Mental Health Center and the Psychiatric Laboratory, West China Hospital, 
      Sichuan University, Chengdu, Sichuan, China; State Key Laboratory of Biotherapy, 
      West China Hospital, Sichuan University, Chengdu, Sichuan, China.
FAU - Huang, Chaohua
AU  - Huang C
AD  - The Mental Health Center and the Psychiatric Laboratory, West China Hospital, 
      Sichuan University, Chengdu, Sichuan, China; State Key Laboratory of Biotherapy, 
      West China Hospital, Sichuan University, Chengdu, Sichuan, China.
FAU - Jiang, Lijun
AU  - Jiang L
AD  - The Mental Health Center and the Psychiatric Laboratory, West China Hospital, 
      Sichuan University, Chengdu, Sichuan, China; State Key Laboratory of Biotherapy, 
      West China Hospital, Sichuan University, Chengdu, Sichuan, China.
FAU - Gong, Qiyong
AU  - Gong Q
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Ziedonis, Doug M
AU  - Ziedonis DM
AD  - Department of Psychiatry, University of Massachusetts Medical School/UMass 
      Memorial Health Care, 55 Lake Avenue North, Worcester, MA 01655, USA.
FAU - King, Jean A
AU  - King JA
AD  - Department of Psychiatry, University of Massachusetts Medical School/UMass 
      Memorial Health Care, 55 Lake Avenue North, Worcester, MA 01655, USA; Center for 
      Comparative Neuroimaging (CCNI), Department of Psychiatry, University of 
      Massachusetts Medical School, 55 Lake Avenue North, Worcester MA, USA.
FAU - Ma, Xiaohong
AU  - Ma X
AD  - The Mental Health Center and the Psychiatric Laboratory, West China Hospital, 
      Sichuan University, Chengdu, Sichuan, China; State Key Laboratory of Biotherapy, 
      West China Hospital, Sichuan University, Chengdu, Sichuan, China.
FAU - Zhang, Nanyin
AU  - Zhang N
AD  - Department of Psychiatry, University of Massachusetts Medical School/UMass 
      Memorial Health Care, 55 Lake Avenue North, Worcester, MA 01655, USA; Center for 
      Comparative Neuroimaging (CCNI), Department of Psychiatry, University of 
      Massachusetts Medical School, 55 Lake Avenue North, Worcester MA, USA; Department 
      of Biomedical Engineering, The Huck Institute of Life Sciences, The Pennsylvania 
      State University, W-341 Millennium Science Complex, University Park, PA 16802, 
      USA. Electronic address: nxzbio@engr.psu.edu.
FAU - Li, Tao
AU  - Li T
AD  - The Mental Health Center and the Psychiatric Laboratory, West China Hospital, 
      Sichuan University, Chengdu, Sichuan, China; State Key Laboratory of Biotherapy, 
      West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic 
      address: xuntao26@hotmail.com.
LA  - eng
GR  - R01NS085200/NS/NINDS NIH HHS/United States
GR  - R01 NS085200/NS/NINDS NIH HHS/United States
GR  - R01 MH098003/MH/NIMH NIH HHS/United States
GR  - WT_/Wellcome Trust/United Kingdom
GR  - R01MH098003/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150311
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*metabolism/pathology
MH  - Brain Mapping/methods
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Nerve Net/*metabolism/pathology
MH  - Schizophrenia/diagnosis/*metabolism
MH  - Young Adult
PMC - PMC4704446
MID - NIHMS707358
OTO - NOTNLM
OT  - Functional connectivity
OT  - Neural networks
OT  - Resting state
OT  - Schizophrenia
OT  - fMRI
EDAT- 2015/03/31 06:00
MHDA- 2015/10/17 06:00
PMCR- 2016/01/07
CRDT- 2015/03/31 06:00
PHST- 2014/01/15 00:00 [received]
PHST- 2014/11/04 00:00 [revised]
PHST- 2015/03/03 00:00 [accepted]
PHST- 2015/03/31 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2015/10/17 06:00 [medline]
PHST- 2016/01/07 00:00 [pmc-release]
AID - S0925-4927(15)00061-X [pii]
AID - 10.1016/j.pscychresns.2015.03.001 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 May 30;232(2):145-53. doi: 
      10.1016/j.pscychresns.2015.03.001. Epub 2015 Mar 11.