PMID- 25819403 OWN - NLM STAT- MEDLINE DCOM- 20160114 LR - 20220318 IS - 1440-1843 (Electronic) IS - 1323-7799 (Linking) VI - 20 IP - 5 DP - 2015 Jul TI - Aetiology of bronchiectasis in Guangzhou, southern China. PG - 739-48 LID - 10.1111/resp.12528 [doi] AB - BACKGROUND AND OBJECTIVE: Aetiologies of bronchiectasis in mainland China and their comparisons with those in western countries are unknown. We aimed to investigate bronchiectasis aetiologies in Guangzhou, southern China, and to determine ethnic or geographic differences with reports from western countries. METHODS: Consecutive patients with steady-state bronchiectasis were randomly recruited. Past history was meticulously extracted. Patients underwent physical examination, saccharine test, humoral immunity assays, gastroesophageal reflux scoring and sputum culture. Fiberoptic bronchoscopy, total immunoglobin E (IgE) and Aspergillus fumigatus-specific IgE measurement, 24-h gastroesophageal pH monitoring and miscellaneous screening tests were performed, if indicated. This entailed comparisons on aetiologies with literature reports. RESULTS: We enrolled 148 patients (44.6 +/- 13.8 years, 92 females), most of whom had mild to moderate bronchiectasis. Idiopathic (46.0%), post-infectious (27.0%) and immunodeficiency (8.8%) were the most common aetiologies. Miscellaneous aetiologies consisted of asthma (5.4%), gastroesophageal reflux (4.1%), aspergillosis (2.7%), congenital lung malformation (2.0%), Kartagener syndrome (1.4%), rheumatoid arthritis (1.4%), chronic obstructive pulmonary disease (0.7%), Young's syndrome (0.7%), yellow nail's syndrome (0.7%), eosinophilic bronchiolitis (0.7%) and foreign bodies (0.7%). No notable differences in clinical characteristics between idiopathic and known aetiologies were found. Ethnic or geographic variations of aetiologies were overall unremarkable. CONCLUSIONS: Idiopathic, post-infectious and immunodeficiency constitute major bronchiectasis aetiologies in Guangzhou. Clinical characteristics of patients between known aetiologies and idiopathic bronchiectasis were similar. Ethnicity and geography only account for limited differences in aetiologic spectra. These findings will offer rationales for early diagnosis and management of bronchiectasis in future studies and clinical practice in China. CI - (c) 2015 Asian Pacific Society of Respirology. FAU - Guan, Wei-Jie AU - Guan WJ AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. FAU - Gao, Yong-Hua AU - Gao YH AD - Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. FAU - Xu, Gang AU - Xu G AD - Department of Geriatrics Medicine, Guangzhou First People's Hospital, Guangzhou, Guangdong, China. FAU - Lin, Zhi-Ya AU - Lin ZY AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. FAU - Tang, Yan AU - Tang Y AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. FAU - Li, Hui-Min AU - Li HM AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. FAU - Lin, Zhi-Min AU - Lin ZM AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. FAU - Zheng, Jin-Ping AU - Zheng JP AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. FAU - Chen, Rong-Chang AU - Chen RC AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. FAU - Zhong, Nan-Shan AU - Zhong NS AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150326 PL - Australia TA - Respirology JT - Respirology (Carlton, Vic.) JID - 9616368 RN - Young Syndrome SB - IM CIN - Respirology. 2015 Oct;20(7):1145. PMID: 26172480 CIN - Respirology. 2015 Oct;20(7):1145-6. PMID: 26172572 MH - Adult MH - Aspergillus fumigatus/immunology/isolation & purification MH - Asthma/complications MH - *Bronchiectasis/diagnosis/ethnology/etiology/physiopathology MH - China/epidemiology MH - Demography MH - Ethnicity MH - Female MH - Gastroesophageal Reflux/complications MH - Humans MH - Immunologic Deficiency Syndromes MH - Kartagener Syndrome/complications MH - Male MH - Middle Aged MH - Oligospermia MH - Pulmonary Disease, Chronic Obstructive/complications MH - Respiratory Tract Infections MH - Severity of Illness Index MH - Tomography, X-Ray Computed MH - Yellow Nail Syndrome/complications OTO - NOTNLM OT - aetiology OT - bronchiectasis OT - clinical characteristic OT - diagnostic test OT - idiopathic EDAT- 2015/03/31 06:00 MHDA- 2016/01/15 06:00 CRDT- 2015/03/31 06:00 PHST- 2014/10/28 00:00 [received] PHST- 2015/01/08 00:00 [revised] PHST- 2014/12/21 00:00 [revised] PHST- 2015/01/13 00:00 [revised] PHST- 2015/01/19 00:00 [accepted] PHST- 2015/03/31 06:00 [entrez] PHST- 2015/03/31 06:00 [pubmed] PHST- 2016/01/15 06:00 [medline] AID - 10.1111/resp.12528 [doi] PST - ppublish SO - Respirology. 2015 Jul;20(5):739-48. doi: 10.1111/resp.12528. Epub 2015 Mar 26.