PMID- 25819613
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20181113
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 86
IP  - 1
DP  - 2015 Apr 8
TI  - Medial prefrontal cortex predicts internally driven strategy shifts.
PG  - 331-40
LID - S0896-6273(15)00211-1 [pii]
LID - 10.1016/j.neuron.2015.03.015 [doi]
AB  - Many daily behaviors require us to actively focus on the current task and ignore 
      all other distractions. Yet, ignoring everything else might hinder the ability to 
      discover new ways to achieve the same goal. Here, we studied the neural 
      mechanisms that support the spontaneous change to better strategies while an 
      established strategy is executed. Multivariate neuroimaging analyses showed that 
      before the spontaneous change to an alternative strategy, medial prefrontal 
      cortex (MPFC) encoded information that was irrelevant for the current strategy 
      but necessary for the later strategy. Importantly, this neural effect was related 
      to future behavioral changes: information encoding in MPFC was changed only in 
      participants who eventually switched their strategy and started before the actual 
      strategy change. This allowed us to predict spontaneous strategy shifts ahead of 
      time. These findings suggest that MPFC might internally simulate alternative 
      strategies and shed new light on the organization of PFC.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Schuck, Nicolas W
AU  - Schuck NW
AD  - Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; 
      Department of Psychology, Humboldt-Universitat zu Berlin, 10099 Berlin, Germany; 
      Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 
      Berlin, Germany. Electronic address: nschuck@princeton.edu.
FAU - Gaschler, Robert
AU  - Gaschler R
AD  - Department of Psychology, Humboldt-Universitat zu Berlin, 10099 Berlin, Germany; 
      Department of Psychology, Universitat Koblenz-Landau, 76829 Landau in der Pfalz, 
      Germany.
FAU - Wenke, Dorit
AU  - Wenke D
AD  - Department of Psychology, Humboldt-Universitat zu Berlin, 10099 Berlin, Germany.
FAU - Heinzle, Jakob
AU  - Heinzle J
AD  - Translational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, 
      University of Zurich and Swiss Federal Institute of Technology (ETH), 8032 
      Zurich, Switzerland; Bernstein Center for Computational Neuroscience, 
      Charite-Universitatsmedizin Berlin, 10115 Berlin, Germany.
FAU - Frensch, Peter A
AU  - Frensch PA
AD  - Department of Psychology, Humboldt-Universitat zu Berlin, 10099 Berlin, Germany.
FAU - Haynes, John-Dylan
AU  - Haynes JD
AD  - Bernstein Center for Computational Neuroscience, Charite-Universitatsmedizin 
      Berlin, 10115 Berlin, Germany; Max Planck Institute for Human Cognitive and Brain 
      Sciences, 04103 Leipzig, Germany; Department of Neurology, Otto-von-Guericke 
      University, 30106 Magdeburg, Germany.
FAU - Reverberi, Carlo
AU  - Reverberi C
AD  - Bernstein Center for Computational Neuroscience, Charite-Universitatsmedizin 
      Berlin, 10115 Berlin, Germany; Department of Psychology, University of 
      Milano-Bicocca, 20126 Milano, Italy; Milan Center for Neuroscience, 20126 Milano, 
      Italy. Electronic address: carlo.reverberi@unimib.it.
LA  - eng
GR  - R01 MH098861/MH/NIMH NIH HHS/United States
GR  - R01MH098861/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150326
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Attention/*physiology
MH  - Decision Making/physiology
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Oxygen/blood
MH  - Photic Stimulation
MH  - Prefrontal Cortex/blood supply/*physiology
MH  - ROC Curve
MH  - Reaction Time/physiology
MH  - Support Vector Machine
MH  - Visual Perception/*physiology
MH  - Young Adult
PMC - PMC4425426
MID - NIHMS675737
EDAT- 2015/03/31 06:00
MHDA- 2015/06/16 06:00
PMCR- 2016/04/08
CRDT- 2015/03/31 06:00
PHST- 2014/08/18 00:00 [received]
PHST- 2014/11/21 00:00 [revised]
PHST- 2015/03/02 00:00 [accepted]
PHST- 2015/03/31 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
PHST- 2016/04/08 00:00 [pmc-release]
AID - S0896-6273(15)00211-1 [pii]
AID - 10.1016/j.neuron.2015.03.015 [doi]
PST - ppublish
SO  - Neuron. 2015 Apr 8;86(1):331-40. doi: 10.1016/j.neuron.2015.03.015. Epub 2015 Mar 
      26.