PMID- 25820061
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20150502
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 33
IP  - 21
DP  - 2015 May 15
TI  - Porcine reproductive and respiratory syndrome virus (PRRSv) modified-live vaccine 
      reduces virus transmission in experimental conditions.
PG  - 2493-9
LID - S0264-410X(15)00339-4 [pii]
LID - 10.1016/j.vaccine.2015.03.040 [doi]
AB  - Some vaccination strategies have shown good results in reducing the clinical 
      outcomes of PRRS. Nevertheless the effect of vaccines on viral transmission is 
      poorly described, so we aimed to fill this gap with the present study. Twelve 
      Specific Pathogen Free (SPF) piglets, vaccinated against PRRSv at 3 weeks of age 
      (Porcilis PRRS ID((R)), MSD), were inoculated at 31 days post-vaccination with a 
      heterologous genogroup 1.1 strain, and put in contact with 12 vaccinated piglets 
      during 49 days. The same protocol was carried out simultaneously with SPF 
      non-vaccinated piglets. Piglets were monitored individually for clinical symptoms 
      on a daily basis and individual blood samples were taken twice a week. In 
      inoculated piglets, the genome viral load specific to the inoculated strain was 
      reduced and viraemia shortened in vaccinated piglets (28 days versus 38 days in 
      non vaccinated piglets). In contact pigs, the challenge strain was detected in 
      the serum of only one vaccinated piglet whereas it was detected in all contact 
      non-vaccinated piglets. Transmission parameters were estimated by a Bayesian 
      analysis of transmission data in the two groups. The estimated transmission rate 
      was 10-times lower in vaccinated than in non-vaccinated piglets and the duration 
      of infectiousness was reduced, leading to a reproduction ratio R significantly 
      lower (0.30 [0.05-0.96] versus 5.42 [2.94-9.04] in non vaccinated piglets). 
      Hence, in our experimental conditions, vaccination was able to decrease 
      considerably PRRSv spread. A complementary evaluation in field conditions would 
      be required to identify circumstances associated with infection control failures 
      that can be observed in pig farms.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Rose, N
AU  - Rose N
AD  - Anses-Laboratoire de Ploufragan-Plouzane, BP 53, 22440 Ploufragan, France; 
      Universite Europeenne de Bretagne, Rennes, France. Electronic address: 
      nicolas.rose@anses.fr.
FAU - Renson, P
AU  - Renson P
AD  - Anses-Laboratoire de Ploufragan-Plouzane, BP 53, 22440 Ploufragan, France; 
      Universite Europeenne de Bretagne, Rennes, France.
FAU - Andraud, M
AU  - Andraud M
AD  - Anses-Laboratoire de Ploufragan-Plouzane, BP 53, 22440 Ploufragan, France; 
      Universite Europeenne de Bretagne, Rennes, France.
FAU - Paboeuf, F
AU  - Paboeuf F
AD  - Anses-Laboratoire de Ploufragan-Plouzane, BP 53, 22440 Ploufragan, France; 
      Universite Europeenne de Bretagne, Rennes, France.
FAU - Le Potier, M F
AU  - Le Potier MF
AD  - Anses-Laboratoire de Ploufragan-Plouzane, BP 53, 22440 Ploufragan, France; 
      Universite Europeenne de Bretagne, Rennes, France.
FAU - Bourry, O
AU  - Bourry O
AD  - Anses-Laboratoire de Ploufragan-Plouzane, BP 53, 22440 Ploufragan, France; 
      Universite Europeenne de Bretagne, Rennes, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150326
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Disease Transmission, Infectious/*prevention & control
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control/transmission
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/isolation & 
      purification
MH  - Swine
MH  - Vaccines, Attenuated/administration & dosage/immunology
MH  - Viral Load
MH  - Viral Vaccines/administration & dosage/*immunology
MH  - Viremia/prevention & control
OTO - NOTNLM
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Reproduction number
OT  - Transmission
OT  - Vaccination
EDAT- 2015/03/31 06:00
MHDA- 2016/01/20 06:00
CRDT- 2015/03/31 06:00
PHST- 2015/01/19 00:00 [received]
PHST- 2015/03/12 00:00 [accepted]
PHST- 2015/03/31 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
AID - S0264-410X(15)00339-4 [pii]
AID - 10.1016/j.vaccine.2015.03.040 [doi]
PST - ppublish
SO  - Vaccine. 2015 May 15;33(21):2493-9. doi: 10.1016/j.vaccine.2015.03.040. Epub 2015 
      Mar 26.