PMID- 25821827
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - Alterations of dendritic cells in sepsis: featured role in immunoparalysis.
PG  - 903720
LID - 10.1155/2015/903720 [doi]
LID - 903720
AB  - Sepsis, the leading cause of mortality in intensive care unit, is characterized 
      by hyperinflammatory response in the early stage and followed by a period of 
      immunosuppression. This immune disorder is believed to be the potent factor that 
      is tightly associated with high mortality in sepsis. Dendritic cells (DCs) serve 
      as professional antigen-presenting cells that play a vital role in immune 
      response by activating T lymphocytes. During the progression of sepsis, DCs have 
      been reported to take part in the aberrant immune response and be necessary for 
      survival. Therefore, a better understanding of the DCs pathology will be 
      undoubtedly beneficial for resolving the problems occurring in sepsis. This 
      review discusses effects of sepsis on DCs number and function, including surface 
      molecules expression, cytokines secretion, and T cell activation, and the 
      underlying mechanism as well as some potential therapeutic strategies.
FAU - Fan, Xia
AU  - Fan X
AUID- ORCID: 0000-0001-8824-1623
AD  - State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of 
      Surgery, Daping Hospital, The Third Military Medical University, Chongqing 
      400042, China.
FAU - Liu, Zheng
AU  - Liu Z
AUID- ORCID: 0000-0003-3223-8403
AD  - State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of 
      Surgery, Daping Hospital, The Third Military Medical University, Chongqing 
      400042, China.
FAU - Jin, He
AU  - Jin H
AUID- ORCID: 0000-0001-5130-6358
AD  - State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of 
      Surgery, Daping Hospital, The Third Military Medical University, Chongqing 
      400042, China.
FAU - Yan, Jun
AU  - Yan J
AD  - State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of 
      Surgery, Daping Hospital, The Third Military Medical University, Chongqing 
      400042, China.
FAU - Liang, Hua-ping
AU  - Liang HP
AD  - State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of 
      Surgery, Daping Hospital, The Third Military Medical University, Chongqing 
      400042, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150302
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/*immunology
MH  - Dendritic Cells/*immunology/*pathology
MH  - Humans
MH  - Models, Immunological
MH  - Sepsis/*immunology/*pathology
MH  - T-Lymphocytes/*immunology/pathology
PMC - PMC4363672
EDAT- 2015/03/31 06:00
MHDA- 2015/12/17 06:00
PMCR- 2015/03/02
CRDT- 2015/03/31 06:00
PHST- 2014/02/15 00:00 [received]
PHST- 2014/05/25 00:00 [revised]
PHST- 2014/07/28 00:00 [accepted]
PHST- 2015/03/31 06:00 [entrez]
PHST- 2015/03/31 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
PHST- 2015/03/02 00:00 [pmc-release]
AID - 10.1155/2015/903720 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:903720. doi: 10.1155/2015/903720. Epub 2015 Mar 2.