PMID- 25823763
OWN - NLM
STAT- MEDLINE
DCOM- 20160127
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 288
DP  - 2015 Jul 15
TI  - Administration of the inverse benzodiazepine agonist MRK-016 rescues acquisition 
      and memory consolidation following peripheral administration of bacterial 
      endotoxin.
PG  - 50-3
LID - S0166-4328(15)00213-2 [pii]
LID - 10.1016/j.bbr.2015.03.048 [doi]
AB  - Recent evidence suggests that inflammation-induced decrements in cognitive 
      function can be mitigated via manipulation of excitatory or inhibitory 
      transmission. We tested the ability of the inverse benzodiazepine agonist, 
      MRK-016 (MRK) to protect against LPS-induced deficits in memory acquisition and 
      consolidation, using a contextual fear conditioning (CFC) paradigm. In Experiment 
      One, mice received lipopolysaccharide (LPS) and/or MRK injections prior to CFC 
      training, and were then tested 24h after training. In Experiment Two, animals 
      received similar treatment injections immediately after training, and were tested 
      24h later. Additionally, hippocampal samples were collected 4h after LPS 
      injections and immediately after testing, to evaluate brain-derived neurotrophic 
      factor (BDNF) and insulin-like growth factor 1 (IGF-1) mRNA expression. Results 
      indicate that MRK can protect against LPS-induced learning/memory decrements in 
      both paradigms. We also found, in both paradigms, that animals treated with 
      LPS/Saline expressed significantly less BDNF mRNA when compared to 
      Saline/Saline-treated animals 4h after LPS administration, but that MRK did not 
      restore BDNF expression levels. Further, treatment administrations had no effect 
      on IGF-1 mRNA expression at any collection time-point. In summary, MRK-016 can 
      protect against LPS-induced deficits in memory acquisition and consolidation, in 
      this hippocampus-dependent paradigm, though this protection occurs independently 
      of recovery of BDNF expression.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Eimerbrink, M J
AU  - Eimerbrink MJ
AD  - Department of Psychology, Neurobiology of Aging Collaborative, Texas Christian 
      University, Fort Worth, TX 76129, USA.
FAU - White, J D
AU  - White JD
AD  - Department of Psychology, Neurobiology of Aging Collaborative, Texas Christian 
      University, Fort Worth, TX 76129, USA.
FAU - Pendry, R J
AU  - Pendry RJ
AD  - Department of Psychology, Neurobiology of Aging Collaborative, Texas Christian 
      University, Fort Worth, TX 76129, USA.
FAU - Hodges, S L
AU  - Hodges SL
AD  - Department of Psychology, Neurobiology of Aging Collaborative, Texas Christian 
      University, Fort Worth, TX 76129, USA.
FAU - Sadler, L N
AU  - Sadler LN
AD  - Department of Psychology, Neurobiology of Aging Collaborative, Texas Christian 
      University, Fort Worth, TX 76129, USA.
FAU - Wiles, J D
AU  - Wiles JD
AD  - Department of Psychology, Neurobiology of Aging Collaborative, Texas Christian 
      University, Fort Worth, TX 76129, USA.
FAU - Weintraub, M K
AU  - Weintraub MK
AD  - Department of Psychology, Neurobiology of Aging Collaborative, Texas Christian 
      University, Fort Worth, TX 76129, USA.
FAU - Chumley, M J
AU  - Chumley MJ
AD  - Department of Biology, Neurobiology of Aging Collaborative, Texas Christian 
      University, Fort Worth, TX 76129, USA.
FAU - Boehm, G W
AU  - Boehm GW
AD  - Department of Psychology, Neurobiology of Aging Collaborative, Texas Christian 
      University, Fort Worth, TX 76129, USA. Electronic address: g.boehm@tcu.edu.
LA  - eng
PT  - Journal Article
DEP - 20150328
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Isoxazoles)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (MRK 016)
RN  - 0 (Nootropic Agents)
RN  - 0 (RNA, Messenger)
RN  - 0 (Triazines)
RN  - 0 (insulin-like growth factor-1, mouse)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Conditioning, Psychological/drug effects/physiology
MH  - Fear/drug effects/physiology
MH  - Freezing Reaction, Cataleptic/drug effects/physiology
MH  - Hippocampus/drug effects/metabolism
MH  - Inflammation/*drug therapy/metabolism/psychology
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Isoxazoles/*pharmacology
MH  - Learning/*drug effects/physiology
MH  - Lipopolysaccharides/*toxicity
MH  - Male
MH  - Memory/*drug effects/physiology
MH  - Mice, Inbred C57BL
MH  - Neuroimmunomodulation/drug effects/physiology
MH  - Nootropic Agents/*pharmacology
MH  - RNA, Messenger/metabolism
MH  - Time Factors
MH  - Triazines/*pharmacology
OTO - NOTNLM
OT  - BDNF
OT  - Hippocampus
OT  - IGF-1
OT  - Inflammation
OT  - LPS
OT  - Lipopolysaccharide
EDAT- 2015/04/01 06:00
MHDA- 2016/01/28 06:00
CRDT- 2015/04/01 06:00
PHST- 2015/01/14 00:00 [received]
PHST- 2015/02/23 00:00 [revised]
PHST- 2015/03/22 00:00 [accepted]
PHST- 2015/04/01 06:00 [entrez]
PHST- 2015/04/01 06:00 [pubmed]
PHST- 2016/01/28 06:00 [medline]
AID - S0166-4328(15)00213-2 [pii]
AID - 10.1016/j.bbr.2015.03.048 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 Jul 15;288:50-3. doi: 10.1016/j.bbr.2015.03.048. Epub 2015 
      Mar 28.