PMID- 25824305
OWN - NLM
STAT- MEDLINE
DCOM- 20160426
LR  - 20181113
IS  - 1476-5578 (Electronic)
IS  - 1359-4184 (Linking)
VI  - 20
IP  - 8
DP  - 2015 Aug
TI  - The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder 
      susceptibility: progress and controversy.
PG  - 916-30
LID - 10.1038/mp.2015.27 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal 
      development, differentiation and plasticity in both the developing and adult 
      brain. A single-nucleotide polymorphism in the proregion of BDNF, termed the 
      Val66Met polymorphism, results in deficient subcellular translocation and 
      activity-dependent secretion of BDNF, and has been associated with impaired 
      neurocognitive function in healthy adults and in the incidence and clinical 
      features of several psychiatric disorders. Research investigating the Val66Met 
      polymorphism has increased markedly in the past decade, and a gap in integration 
      exists between and within academic subfields interested in the effects of this 
      variant. Here we comprehensively review the role and relevance of the Val66Met 
      polymorphism in psychiatric disorders, with emphasis on suicidal behavior and 
      anxiety, eating, mood and psychotic disorders. The cognitive and molecular 
      neuroscience of the Val66Met polymorphism is also concisely reviewed to 
      illustrate the effects of this genetic variant in healthy controls, and is 
      complemented by a commentary on the behavioral neuroscience of BDNF and the 
      Val66Met polymorphism where relevant to specific disorders. Lastly, a number of 
      controversies and unresolved issues, including small effect sizes, sampling of 
      allele inheritance but not genotype and putative ethnicity-specific effects of 
      the Val66Met polymorphism, are also discussed to direct future research.
FAU - Notaras, M
AU  - Notaras M
AD  - Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia.
FAU - Hill, R
AU  - Hill R
AD  - Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia.
FAU - van den Buuse, M
AU  - van den Buuse M
AD  - 1] Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia 
      [2] School of Psychological Science, La Trobe University, Melbourne, VIC, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150331
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Mental Disorders/*genetics/metabolism
MH  - *Polymorphism, Single Nucleotide
EDAT- 2015/04/01 06:00
MHDA- 2016/04/27 06:00
CRDT- 2015/04/01 06:00
PHST- 2014/09/16 00:00 [received]
PHST- 2014/12/22 00:00 [revised]
PHST- 2015/02/09 00:00 [accepted]
PHST- 2015/04/01 06:00 [entrez]
PHST- 2015/04/01 06:00 [pubmed]
PHST- 2016/04/27 06:00 [medline]
AID - mp201527 [pii]
AID - 10.1038/mp.2015.27 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2015 Aug;20(8):916-30. doi: 10.1038/mp.2015.27. Epub 2015 Mar 31.