PMID- 25824310
OWN - NLM
STAT- MEDLINE
DCOM- 20160211
LR  - 20150505
IS  - 1879-1506 (Electronic)
IS  - 0003-9969 (Linking)
VI  - 60
IP  - 6
DP  - 2015 Jun
TI  - Porphyromonas gingivalis-induced alveolar bone loss is accelerated in the 
      stroke-prone spontaneously hypertensive rat.
PG  - 911-8
LID - S0003-9969(15)00040-0 [pii]
LID - 10.1016/j.archoralbio.2015.02.012 [doi]
AB  - Porphyromonas gingivalis (P. gingivalis) is one of the prominent periodontal 
      pathogens and is the most important bacteria involved in the onset and 
      exacerbation of periodontitis. P. gingivalis is an anaerobic, Gram-negative 
      coccobacillus that plays a role in the progression of periodontal disease by 
      promoting alveolar bone resorption. The aim of the present study was to examine 
      P. gingivalis-induced osteoclastic bone resorption in the stroke-prone 
      spontaneously hypertensive rat (SHRSP), in which oxidative stress induced by 
      reactive oxygen species (ROS) is increased. In the present study, we used animals 
      orally challenged with P. gingivalis as a chronic inflammation model. Horizontal 
      bone loss around the maxillary molars was assessed morphometrically. Animals were 
      divided into four groups: (1) P. gingivalis-non-infected Wister Kyoto Rat (WKY), 
      (2) orally challenged with P. gingivalis WKY (WKY + Pg), (3) P. 
      gingivalis-non-infected SHRSP, and (4) orally challenged with P. gingivalis SHRSP 
      (SHRSP + Pg). Alveolar bone resorption was significantly increased in the orally 
      challenged with P. gingivalis groups, and was accelerated in the SHRSP group. 
      Histological analysis revealed that the infiltration of inflammatory cells was 
      absent in all groups. However, the infiltration of osteoclasts was observed in 
      the SHRSP + Pg and SHRSP groups. We examined P. gingivalis-induced alveolar bone 
      loss in both the SHRSP and WKY. The results obtained demonstrated that P. 
      gingivalis-induced alveolar bone loss would be involved in hypertension and 
      stroke animal model, such as SHRSP and/or periodontal disease.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Tokutomi, Fumiaki
AU  - Tokutomi F
AD  - Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental 
      University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan.
FAU - Wada-Takahashi, Satoko
AU  - Wada-Takahashi S
AD  - Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental 
      University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan.
FAU - Sugiyama, Shuta
AU  - Sugiyama S
AD  - Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental 
      University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan.
FAU - Toyama, Toshizo
AU  - Toyama T
AD  - Department of Infection Control, Division of Microbiology, Graduate School of 
      Dentistry, Kanagawa Dental University, Kanagawa, Japan.
FAU - Sato, Takenori
AU  - Sato T
AD  - Department of Infection Control, Division of Microbiology, Graduate School of 
      Dentistry, Kanagawa Dental University, Kanagawa, Japan.
FAU - Hamada, Nobushiro
AU  - Hamada N
AD  - Department of Infection Control, Division of Microbiology, Graduate School of 
      Dentistry, Kanagawa Dental University, Kanagawa, Japan.
FAU - Tsukinoki, Keiichi
AU  - Tsukinoki K
AD  - Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental 
      University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan.
FAU - Takahashi, Shun-suke
AU  - Takahashi SS
AD  - Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental 
      University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan. Electronic 
      address: takahashi.shunsuke@kdu.ac.jp.
FAU - Lee, Masaichi Chang-il
AU  - Lee MC
AD  - Yokosuka-Shonan Disaster Health Emergency Research Center & ESR Laboratories, 
      Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka-cho, 
      Yokosuka, Kanagawa 238-8580, Japan. Electronic address: lee@kdu.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150221
PL  - England
TA  - Arch Oral Biol
JT  - Archives of oral biology
JID - 0116711
SB  - IM
MH  - Alveolar Bone Loss/*microbiology
MH  - Animals
MH  - Bacteroidaceae Infections/*complications/microbiology
MH  - Disease Models, Animal
MH  - Male
MH  - Oxidative Stress
MH  - Periodontitis/*complications/microbiology
MH  - Porphyromonas gingivalis
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Wistar
MH  - Stroke/*etiology
OTO - NOTNLM
OT  - Bone biology
OT  - Inflammation and innate immunity
OT  - Oxidative stress
OT  - Periodontal medicine
OT  - Periodontitis
OT  - Reactive oxygen species (ROS)
EDAT- 2015/04/01 06:00
MHDA- 2016/02/13 06:00
CRDT- 2015/04/01 06:00
PHST- 2014/05/08 00:00 [received]
PHST- 2014/11/27 00:00 [revised]
PHST- 2015/02/13 00:00 [accepted]
PHST- 2015/04/01 06:00 [entrez]
PHST- 2015/04/01 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
AID - S0003-9969(15)00040-0 [pii]
AID - 10.1016/j.archoralbio.2015.02.012 [doi]
PST - ppublish
SO  - Arch Oral Biol. 2015 Jun;60(6):911-8. doi: 10.1016/j.archoralbio.2015.02.012. 
      Epub 2015 Feb 21.