PMID- 25825356
OWN - NLM
STAT- MEDLINE
DCOM- 20170322
LR  - 20181202
IS  - 1995-9133 (Electronic)
IS  - 1684-1182 (Linking)
VI  - 50
IP  - 1
DP  - 2017 Feb
TI  - Toll-like receptor 1 N248S polymorphism affects T helper 1 cytokine production 
      and is associated with serum immunoglobulin E levels in Taiwanese allergic 
      patients.
PG  - 112-117
LID - S1684-1182(15)00028-6 [pii]
LID - 10.1016/j.jmii.2015.01.004 [doi]
AB  - BACKGROUND/PURPOSE: This study was carried out to investigate whether toll-like 
      receptor-1 (TLR1) rs4833095 (N248S) variant, common in the Taiwanese population, 
      contributes to pathogenesis of allergy. METHODS: TLR2/1 ligand 
      Pam3CSK4-stimulated cytokine production in peripheral blood mononuclear cells and 
      monocyte-derived dendritic cells of different genotypes were measured via 
      enzyme-linked immunosorbent assay. Ninety-three Taiwanese allergic patients (with 
      asthma, allergic rhinitis, or atopic dermatitis) and 76 controls were recruited 
      for genotyping. Serum immunoglobulin E (IgE) levels were evaluated in 60 allergic 
      patients. RESULTS: The homozygous TLR1 C variant allele carrier had increased 
      Pam3CSK4-induced tumor necrosis factor-alpha and interleukin-12 responses in 
      peripheral blood mononuclear cells and monocyte-derived dendritic cells, 
      respectively. Furthermore, although the C/C genotype was not associated with 
      susceptibility to atopic diseases, it was correlated with lower total IgE levels 
      in sera of allergic patients. CONCLUSION: Our data suggest that the TLR1 N248S 
      polymorphism might play a role in Th1/Th2 differentiation, and the determination 
      of serum IgE levels. However, interactions with other genetic and environmental 
      factors might be required to contribute to risk of allergic diseases in our 
      population.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Yang, Chin-An
AU  - Yang CA
AD  - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
FAU - Chiang, Bor-Luen
AU  - Chiang BL
AD  - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; 
      Medical Research, National Taiwan University Hospital, Taipei, Taiwan. Electronic 
      address: gicmbor@ntu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20150130
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 0 (Cytokines)
RN  - 0 (Toll-Like Receptor 1)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotyping Techniques
MH  - Humans
MH  - Hypersensitivity/*genetics/pathology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - *Mutation, Missense
MH  - Polymorphism, Genetic
MH  - Serum/chemistry
MH  - Taiwan
MH  - Th1 Cells/*immunology
MH  - Toll-Like Receptor 1/*genetics
OTO - NOTNLM
OT  - Allergy
OT  - Genetic polymorphism
OT  - Immunoglobulin E
OT  - Toll-like receptor
EDAT- 2015/04/01 06:00
MHDA- 2017/03/23 06:00
CRDT- 2015/04/01 06:00
PHST- 2014/06/24 00:00 [received]
PHST- 2014/11/15 00:00 [revised]
PHST- 2015/01/19 00:00 [accepted]
PHST- 2015/04/01 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
PHST- 2015/04/01 06:00 [entrez]
AID - S1684-1182(15)00028-6 [pii]
AID - 10.1016/j.jmii.2015.01.004 [doi]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2017 Feb;50(1):112-117. doi: 
      10.1016/j.jmii.2015.01.004. Epub 2015 Jan 30.