PMID- 25825370
OWN - NLM
STAT- MEDLINE
DCOM- 20151127
LR  - 20181202
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 45
DP  - 2015 Apr
TI  - Altered attention networks in benign childhood epilepsy with centrotemporal 
      spikes (BECTS): A resting-state fMRI study.
PG  - 234-41
LID - S1525-5050(15)00023-2 [pii]
LID - 10.1016/j.yebeh.2015.01.016 [doi]
AB  - It is noteworthy that some children with benign childhood epilepsy with 
      centrotemporal spikes (BECTS) show attention problems despite their favorable 
      seizure outcome. Resting-state functional magnetic resonance imaging (fMRI) is a 
      method widely used to detect brain network alterations in neuropsychiatric 
      diseases. We used resting-state functional magnetic resonance imaging (fMRI) to 
      investigate specific brain networks related to attention deficit in children with 
      BECTS. Resting-state fMRI was performed in patients with BECTS with ADHD (n=15) 
      and those with BECTS without ADHD (n=15) and in healthy controls (n=15). Unbiased 
      seed-based whole-brain functional connectivity analysis was used to study the 
      connectivity pattern of three resting-state networks, including the ventral 
      attention network (VAN) and the dorsal attention network (DAN) and the default 
      mode network (DMN). Patients with BECTS with ADHD displayed decreased functional 
      connectivity in the DAN compared with other two groups, while patients with BECTS 
      without ADHD showed increased functional connectivity in the DAN. Moreover, we 
      found increased functional connectivity in the VAN and in the DMN in patients 
      with BECTS with or without ADHD when comparing with controls. These results 
      showed that the newly-diagnosed children with BECTS displayed brain activity 
      alterations in the ventral and dorsal attention networks. The difference in the 
      extent of impairment in the dorsal attention network of patients with BECTS with 
      ADHD and patients with BECTS without ADHD may lead to improved understanding of 
      the underlying neuropathophysiology and treatment of BECTS with ADHD and BECTS 
      without ADHD.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Xiao, Fenglai
AU  - Xiao F
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Li, Lei
AU  - Li L
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, People's Republic of China.
FAU - An, Dongmei
AU  - An D
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Lei, Du
AU  - Lei D
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, People's Republic of China.
FAU - Tang, Yingying
AU  - Tang Y
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Yang, Tianhua
AU  - Yang T
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Ren, Jiechuan
AU  - Ren J
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Chen, Sihan
AU  - Chen S
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, People's Republic of China.
FAU - Huang, Xiaoqi
AU  - Huang X
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, People's Republic of China.
FAU - Gong, Qiyong
AU  - Gong Q
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, People's Republic of China. Electronic address: 
      zhoudong66@yahoo.de.
FAU - Zhou, Dong
AU  - Zhou D
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, People's Republic of China. Electronic address: qiyonggong@hmrrc.org.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150329
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Attention/physiology
MH  - Attention Deficit Disorder with 
      Hyperactivity/diagnosis/metabolism/*physiopathology
MH  - Brain/metabolism/*physiopathology
MH  - Brain Mapping/methods
MH  - Child
MH  - Child, Preschool
MH  - Epilepsy, Rolandic/diagnosis/metabolism/*physiopathology
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging/methods
MH  - Male
MH  - Nerve Net/metabolism/*physiopathology
MH  - Neural Pathways/metabolism/physiopathology
MH  - *Rest/physiology
OTO - NOTNLM
OT  - Attention deficit and hyperactivity disorder
OT  - Benign childhood epilepsy with centrotemporal spikes
OT  - Functional connectivity
OT  - fMRI
EDAT- 2015/04/01 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/04/01 06:00
PHST- 2014/12/02 00:00 [received]
PHST- 2015/01/03 00:00 [revised]
PHST- 2015/01/12 00:00 [accepted]
PHST- 2015/04/01 06:00 [entrez]
PHST- 2015/04/01 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S1525-5050(15)00023-2 [pii]
AID - 10.1016/j.yebeh.2015.01.016 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2015 Apr;45:234-41. doi: 10.1016/j.yebeh.2015.01.016. Epub 2015 
      Mar 29.