PMID- 25826234
OWN - NLM
STAT- MEDLINE
DCOM- 20160628
LR  - 20240518
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Print)
IS  - 1096-620X (Linking)
VI  - 18
IP  - 8
DP  - 2015 Aug
TI  - Effects of Mung Bean (Vigna radiata L.) Ethanol Extracts Decrease Proinflammatory 
      Cytokine-Induced Lipogenesis in the KK-Ay Diabese Mouse Model.
PG  - 841-9
LID - 10.1089/jmf.2014.3364 [doi]
AB  - Rapid increase in the prevalence of obesity-related metabolic inflammatory 
      diseases has led to research focused on nutraceuticals for their treatment. This 
      study investigated the effects of the ethanol extracts of mung bean testa (MBT) 
      on the metabolic inflammation-induced lipogenesis in gastrocnemius muscle of 
      KK-Ay diabese mice. Ethanol extracts of MBT were orally administered to diabese 
      KK-Ay mice for 4 weeks after diet-induced obesity model was generated by feeding 
      a 60% high-fat diet for 3 weeks. Although there were no changes in body weight 
      gain, MBT treatments decreased total weight of white adipose tissue. MBT also 
      decreased triacylglycerol and total cholesterol levels in the muscle by 30%, 
      which was correlated with suppression of lipogenic genes such as ACC, C/EBP 
      alpha, PGC-1 alpha, and PPAR gamma. In particular, decreased levels of p-ERK1/2, 
      PPAR gamma, and C/EBP alpha in the MBT-treated groups suggest that MBT might 
      inhibit adipogenesis and decrease differentiation via the MEK/ERK pathway. 
      Furthermore, significantly lower amounts of plasma interleukin (IL)-6 and 
      intramuscular tumor necrosis factor (TNF)-alpha and monocyte chemoattractant 
      protein-1 (MCP-1) were detected in MBT groups, confirming the anti-inflammatory 
      effect of mung bean. In addition, our in vitro pilot study with 3T3-L1 cells 
      showed that vitexin, the functional chemical in MBT, inhibited 
      inflammation-induced lipogenesis with significantly lower amounts of IL-6 and 
      MCP-1 after 14 days of vitexin treatment. Thus, the functional compounds in the 
      mung bean ethanol extracts such as vitexin and isovitexin may regulate 
      intracellular lipogenesis and adipogenesis via anti-inflammatory mechanisms and 
      MEK/ERK pathway in the KK-Ay mouse model.
FAU - Kang, Inhae
AU  - Kang I
AD  - 1 Department of Nutrition and Health Sciences, University of Nebraska-Lincoln , 
      Lincoln, Nebraska.
FAU - Choi, Seojin
AU  - Choi S
AD  - 2 Department of Food and Nutrition, Research Institute of Obesity Sciences, 
      Sungshin Women's University , Seoul, Korea.
FAU - Ha, Tae Joung
AU  - Ha TJ
AD  - 3 Department of Functional Crop, National Institute of Crop Science , RDA, 
      Miryang, Korea.
FAU - Choi, Munji
AU  - Choi M
AD  - 2 Department of Food and Nutrition, Research Institute of Obesity Sciences, 
      Sungshin Women's University , Seoul, Korea.
FAU - Wi, Hae-Ri
AU  - Wi HR
AD  - 2 Department of Food and Nutrition, Research Institute of Obesity Sciences, 
      Sungshin Women's University , Seoul, Korea.
FAU - Lee, Byong Won
AU  - Lee BW
AD  - 3 Department of Functional Crop, National Institute of Crop Science , RDA, 
      Miryang, Korea.
FAU - Lee, Myoungsook
AU  - Lee M
AD  - 2 Department of Food and Nutrition, Research Institute of Obesity Sciences, 
      Sungshin Women's University , Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150331
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Plant Extracts)
RN  - 0 (Triglycerides)
RN  - 3K9958V90M (Ethanol)
RN  - 7V515PI7F6 (Apigenin)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - 9VP70K75OK (vitexin)
RN  - KTQ9R9MS0Q (isovitexin)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipose Tissue, White/drug effects/metabolism
MH  - Animals
MH  - Apigenin/pharmacology
MH  - Body Weight/drug effects
MH  - Chemokine CCL2/metabolism
MH  - Cholesterol/metabolism
MH  - Cytokines/*metabolism
MH  - Diabetes Mellitus, Type 2/*diet therapy/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Disease Models, Animal
MH  - Ethanol/chemistry
MH  - Fabaceae/*chemistry
MH  - Inflammation/*diet therapy/metabolism
MH  - Interleukin-6/metabolism
MH  - Lipogenesis/*drug effects
MH  - MAP Kinase Signaling System/genetics
MH  - Male
MH  - Mice
MH  - Obesity/*diet therapy/metabolism
MH  - Plant Extracts/chemistry/pharmacology
MH  - Triglycerides/metabolism
PMC - PMC4523062
OTO - NOTNLM
OT  - C/EBPalpha
OT  - ERK1/2
OT  - PGC-1alpha
OT  - PPARgamma
OT  - Vigna radiata L.
OT  - adipogenesis
OT  - adipokines
OT  - diabese
OT  - metabolic inflammation
OT  - mung bean
EDAT- 2015/04/01 06:00
MHDA- 2016/06/29 06:00
PMCR- 2016/08/01
CRDT- 2015/04/01 06:00
PHST- 2015/04/01 06:00 [entrez]
PHST- 2015/04/01 06:00 [pubmed]
PHST- 2016/06/29 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - 10.1089/jmf.2014.3364 [pii]
AID - 10.1089/jmf.2014.3364 [doi]
PST - ppublish
SO  - J Med Food. 2015 Aug;18(8):841-9. doi: 10.1089/jmf.2014.3364. Epub 2015 Mar 31.