PMID- 25826372
OWN - NLM
STAT- MEDLINE
DCOM- 20160327
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 3
DP  - 2015
TI  - MicroRNA-22 impairs anti-tumor ability of dendritic cells by targeting p38.
PG  - e0121510
LID - 10.1371/journal.pone.0121510 [doi]
LID - e0121510
AB  - Dendritic cells (DCs) play a critical role in triggering anti-tumor immune 
      responses. Their intracellular p38 signaling is of great importance in 
      controlling DC activity. In this study, we identified microRNA-22 (miR-22) as a 
      microRNA inhibiting p38 protein expression by directly binding to the 3' 
      untranslated region (3'UTR) of its mRNA. The p38 down-regulation further 
      interfered with the synthesis of DC-derived IL-6 and the differentiation of 
      DC-driven Th17 cells. Moreover, overexpression of miR-22 in DCs impaired their 
      tumor-suppressing ability while miR-22 inhibitor could reverse this phenomenon 
      and improve the curative effect of DC-based immunotherapy. Thus, our results 
      highlight a suppressive role for miR-22 in the process of DC-invoked anti-tumor 
      immunity and that blocking this microRNA provides a new strategy for generating 
      potent DC vaccines for patients with cancer.
FAU - Liang, Xue
AU  - Liang X
AD  - Department of Immunology, Nankai University School of Medicine, Tianjin, China; 
      Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, 
      Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of 
      Tianjin Medical University, Tianjin, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Immunology, Nankai University School of Medicine, Tianjin, China.
FAU - Mei, Shiyue
AU  - Mei S
AD  - Department of Immunology, Nankai University School of Medicine, Tianjin, China.
FAU - Zhang, Miaomiao
AU  - Zhang M
AD  - Department of Immunology, Nankai University School of Medicine, Tianjin, China.
FAU - Xin, Jiaxuan
AU  - Xin J
AD  - Department of Immunology, Nankai University School of Medicine, Tianjin, China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Department of Immunology, Nankai University School of Medicine, Tianjin, China.
FAU - Yang, Rongcun
AU  - Yang R
AD  - Department of Immunology, Nankai University School of Medicine, Tianjin, China; 
      State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 
      China; Key Laboratory of Bioactive Materials, Ministry of Education, Nankai 
      University, Tianjin, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150331
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (3' Untranslated Regions)
RN  - 0 (MicroRNAs)
RN  - 0 (Mirn22 microRNA, mouse)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Animals
MH  - Cell Line
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - MicroRNAs/*physiology
MH  - p38 Mitogen-Activated Protein Kinases/*metabolism
PMC - PMC4380340
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/04/01 06:00
MHDA- 2016/03/28 06:00
PMCR- 2015/03/31
CRDT- 2015/04/01 06:00
PHST- 2014/08/21 00:00 [received]
PHST- 2015/02/12 00:00 [accepted]
PHST- 2015/04/01 06:00 [entrez]
PHST- 2015/04/01 06:00 [pubmed]
PHST- 2016/03/28 06:00 [medline]
PHST- 2015/03/31 00:00 [pmc-release]
AID - PONE-D-14-28769 [pii]
AID - 10.1371/journal.pone.0121510 [doi]
PST - epublish
SO  - PLoS One. 2015 Mar 31;10(3):e0121510. doi: 10.1371/journal.pone.0121510. 
      eCollection 2015.