PMID- 25827511
OWN - NLM
STAT- MEDLINE
DCOM- 20160115
LR  - 20220331
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Print)
IS  - 1444-0903 (Linking)
VI  - 45
IP  - 4
DP  - 2015 Apr
TI  - Appropriate clinical use of human leukocyte antigen typing for coeliac disease: 
      an Australasian perspective.
PG  - 441-50
LID - 10.1111/imj.12716 [doi]
AB  - The past decade has seen human leukocyte antigen (HLA) typing emerge as a 
      remarkably popular test for the diagnostic work-up of coeliac disease with high 
      patient acceptance. Although limited in its positive predictive value for coeliac 
      disease, the strong disease association with specific HLA genes imparts 
      exceptional negative predictive value to HLA typing, enabling a negative result 
      to exclude coeliac disease confidently. In response to mounting evidence that the 
      clinical use and interpretation of HLA typing often deviates from best practice, 
      this article outlines an evidence-based approach to guide clinically appropriate 
      use of HLA typing, and establishes a reporting template for pathology providers 
      to improve communication of results.
CI  - (c) 2015 The Authors. Internal Medicine Journal published by Wiley Publishing Asia 
      Pty Ltd on behalf of Royal Australasian College of Physicians.
FAU - Tye-Din, J A
AU  - Tye-Din JA
AD  - Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 
      Melbourne, Victoria, Australia; Departments of Medical Biology, The University of 
      Melbourne, Melbourne, Victoria, Australia; Department of Gastroenterology, The 
      Royal Melbourne Hospital, Melbourne, Victoria, Australia; Medical Advisory 
      Committee, Coeliac Australia, Melbourne, Victoria, Australia.
FAU - Cameron, D J S
AU  - Cameron DJ
FAU - Daveson, A J
AU  - Daveson AJ
FAU - Day, A S
AU  - Day AS
FAU - Dellsperger, P
AU  - Dellsperger P
FAU - Hogan, C
AU  - Hogan C
FAU - Newnham, E D
AU  - Newnham ED
FAU - Shepherd, S J
AU  - Shepherd SJ
FAU - Steele, R H
AU  - Steele RH
FAU - Wienholt, L
AU  - Wienholt L
FAU - Varney, M D
AU  - Varney MD
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Australasia/epidemiology
MH  - Celiac Disease/blood/*epidemiology/*genetics
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - HLA Antigens/blood/*genetics
MH  - Histocompatibility Testing/methods/*statistics & numerical data
MH  - Humans
PMC - PMC4405087
OTO - NOTNLM
OT  - HLA typing
OT  - coeliac disease
OT  - diagnostics
EDAT- 2015/04/02 06:00
MHDA- 2016/01/16 06:00
PMCR- 2015/04/21
CRDT- 2015/04/02 06:00
PHST- 2014/09/03 00:00 [received]
PHST- 2015/01/08 00:00 [accepted]
PHST- 2015/04/02 06:00 [entrez]
PHST- 2015/04/02 06:00 [pubmed]
PHST- 2016/01/16 06:00 [medline]
PHST- 2015/04/21 00:00 [pmc-release]
AID - 10.1111/imj.12716 [doi]
PST - ppublish
SO  - Intern Med J. 2015 Apr;45(4):441-50. doi: 10.1111/imj.12716.