PMID- 25827839
OWN - NLM
STAT- MEDLINE
DCOM- 20160615
LR  - 20150521
IS  - 1477-9145 (Electronic)
IS  - 0022-0949 (Linking)
VI  - 218
IP  - Pt 10
DP  - 2015 May 15
TI  - Ammonia first? The transition from cutaneous to branchial ammonia excretion in 
      developing rainbow trout is not altered by exposure to chronically high NaCl.
PG  - 1467-70
LID - 10.1242/jeb.119362 [doi]
AB  - Larval rainbow trout (Oncorhynchus mykiss) were reared from hatch under control 
      ([Na(+)]=0.60 mmol l(-1)) or high NaCl ([Na(+)]=60 mmol l(-1)) conditions to 
      elucidate the driving force for the ontogeny of branchial Na(+)/NH4 (+) exchange, 
      one of the earliest gill functions. We hypothesized that if Na(+) uptake is the 
      driving force, then in high NaCl there would be a delay in the skin-to-gill shift 
      in ammonia excretion (Jamm) and/or an elevation in whole-body total ammonia 
      (Tamm). In both groups, however, the skin-to-gill shift for Jamm, determined 
      using divided chambers, occurred at the same time (13 days post-hatch; dph) and 
      whole-body Tamm was unchanged. Moreover, high NaCl larvae displayed elevated 
      whole-body [Na(+)] relative to controls by 18 dph, suggesting that maintaining 
      branchial Jamm occurs at the expense of Na(+) balance. Overall, these results 
      support the 'ammonia hypothesis', which posits that ammonia excretion, probably 
      as Na(+)/NH4 (+) exchange, is the primary function of the early fish gill.
CI  - (c) 2015. Published by The Company of Biologists Ltd.
FAU - Zimmer, Alex M
AU  - Zimmer AM
AD  - Department of Biology, McMaster University, Hamilton, ON, Canada L8S 4K1 
      zimmea@mcmaster.ca.
FAU - Wood, Chris M
AU  - Wood CM
AD  - Department of Biology, McMaster University, Hamilton, ON, Canada L8S 4K1 
      Department of Zoology, University of British Columbia, Vancouver, BC, Canada V6T 
      1Z4 Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, 
      Miami, FL 33149, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150331
PL  - England
TA  - J Exp Biol
JT  - The Journal of experimental biology
JID - 0243705
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 7664-41-7 (Ammonia)
SB  - IM
MH  - Ammonia/*metabolism
MH  - Animals
MH  - Gills/growth & development/metabolism
MH  - Larva/metabolism
MH  - Oncorhynchus mykiss/growth & development/*metabolism
MH  - Salinity
MH  - Skin/growth & development/metabolism
MH  - Sodium Chloride/*metabolism
OTO - NOTNLM
OT  - Ammonia excretion (Jamm)
OT  - Ammonia hypothesis
OT  - Gill development
OT  - Ionoregulatory hypothesis
OT  - Na+ uptake
OT  - Na+/K+-ATPase
OT  - Oncorhynchus mykiss
EDAT- 2015/04/02 06:00
MHDA- 2016/06/16 06:00
CRDT- 2015/04/02 06:00
PHST- 2015/01/13 00:00 [received]
PHST- 2015/03/10 00:00 [accepted]
PHST- 2015/04/02 06:00 [entrez]
PHST- 2015/04/02 06:00 [pubmed]
PHST- 2016/06/16 06:00 [medline]
AID - jeb.119362 [pii]
AID - 10.1242/jeb.119362 [doi]
PST - ppublish
SO  - J Exp Biol. 2015 May 15;218(Pt 10):1467-70. doi: 10.1242/jeb.119362. Epub 2015 
      Mar 31.