PMID- 25828164
OWN - NLM
STAT- MEDLINE
DCOM- 20160113
LR  - 20191210
IS  - 1873-4138 (Electronic)
IS  - 0309-1740 (Linking)
VI  - 105
DP  - 2015 Jul
TI  - Simple and sensitive monitoring of beta2-agonist residues in meat by liquid 
      chromatography-tandem mass spectrometry using a QuEChERS with preconcentration as 
      the sample treatment.
PG  - 96-107
LID - S0309-1740(15)00074-1 [pii]
LID - 10.1016/j.meatsci.2015.03.013 [doi]
AB  - A liquid chromatography with tandem mass spectrometric detection (LC-MS/MS) 
      method was established for the simultaneous determination of the levels of 10 
      beta2-agonists in meat. The samples were extracted using an aqueous acidic solution 
      and cleaned up using a Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) 
      technique utilising a DVB-NVP-SO3Na sorbent synthesised in-house. First, the 
      beta2-agonist residues were extracted in an aqueous acidic solution, followed by 
      matrix solid-phase dispersion for clean-up. The linearities of the method were 
      R(2)=0.9925-0.9998, with RSDs of 2.7-15.3% and 73.7-103.5% recoveries. Very low 
      limits of detection (LOD) and quantitation (LOQ) of 0.2-0.9 mug/kg and 0.8-3.2 
      mug/kg, respectively, were achieved for spiked meat. The values obtained were 
      lower than the maximum residue limits (MRLs) established by the EU and China. 
      These results clearly demonstrate the feasibility of the proposed approach. The 
      evaluated method provided reliable screening, quantification and identification 
      of 10 beta2-agonists in meat.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Xiong, Lin
AU  - Xiong L
AD  - Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of 
      Agricultural Sciences, Lanzhou 730050, China; Laboratory of Quality & Safety Risk 
      Assessment for Livestock Product (Lanzhou), Ministry of Agriculture, Lanzhou 
      730050, China. Electronic address: xionglin807@sina.com.
FAU - Gao, Ya-Qin
AU  - Gao YQ
AD  - Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of 
      Agricultural Sciences, Lanzhou 730050, China; Laboratory of Quality & Safety Risk 
      Assessment for Livestock Product (Lanzhou), Ministry of Agriculture, Lanzhou 
      730050, China.
FAU - Li, Wei-Hong
AU  - Li WH
AD  - Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of 
      Agricultural Sciences, Lanzhou 730050, China; Laboratory of Quality & Safety Risk 
      Assessment for Livestock Product (Lanzhou), Ministry of Agriculture, Lanzhou 
      730050, China.
FAU - Yang, Xiao-Lin
AU  - Yang XL
AD  - Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of 
      Agricultural Sciences, Lanzhou 730050, China; Laboratory of Quality & Safety Risk 
      Assessment for Livestock Product (Lanzhou), Ministry of Agriculture, Lanzhou 
      730050, China.
FAU - Shimo, Shimo Peter
AU  - Shimo SP
AD  - Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of 
      Agricultural Sciences, Lanzhou 730050, China; Laboratory of Quality & Safety Risk 
      Assessment for Livestock Product (Lanzhou), Ministry of Agriculture, Lanzhou 
      730050, China.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150320
PL  - England
TA  - Meat Sci
JT  - Meat science
JID - 101160862
RN  - 0 (Adrenergic beta-2 Receptor Agonists)
RN  - 0 (Ethanolamines)
RN  - 0 (Ion Exchange Resins)
RN  - 0 (Phenethylamines)
RN  - 57370OZ3P1 (ractopamine)
SB  - IM
MH  - Adrenergic beta-2 Receptor Agonists/*analysis/chemistry
MH  - Analytic Sample Preparation Methods
MH  - Animals
MH  - Cattle
MH  - China
MH  - Chromatography, High Pressure Liquid
MH  - Drug Residues/*analysis/chemistry
MH  - Ethanolamines/*analysis/chemistry
MH  - European Union
MH  - *Food Contamination
MH  - Food Inspection/*methods/standards
MH  - Ion Exchange Resins/chemical synthesis/chemistry
MH  - Limit of Detection
MH  - Meat/*analysis/standards
MH  - Molecular Structure
MH  - Phenethylamines/*analysis/chemistry
MH  - Reproducibility of Results
MH  - Solid Phase Extraction
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Cimaterol (PubChem CID: 277)
OT  - Clenbuterol (PubChem CID: 2783)
OT  - Clorprenaline (PubChem CID: 23360)
OT  - DVB-NVP-SO(3)Na
OT  - Feed additive
OT  - Fenoterol (PubChem CID: 3343)
OT  - LC-MS/MS
OT  - Meat
OT  - Penbuterol (PubChem CID: 4845)
OT  - Phenylethanolamine A (PubChem CID: 3039588)
OT  - QuEChERS
OT  - Ractopamine (PubChem CID: 56052)
OT  - Salbutamol (PubChem CID: 2083)
OT  - Terbutaline (PubChem CID: 5403)
OT  - Tulobuterol (PubChem CID: 5606)
OT  - beta(2)-Agonists
EDAT- 2015/04/02 06:00
MHDA- 2016/01/14 06:00
CRDT- 2015/04/02 06:00
PHST- 2014/07/18 00:00 [received]
PHST- 2015/03/10 00:00 [revised]
PHST- 2015/03/12 00:00 [accepted]
PHST- 2015/04/02 06:00 [entrez]
PHST- 2015/04/02 06:00 [pubmed]
PHST- 2016/01/14 06:00 [medline]
AID - S0309-1740(15)00074-1 [pii]
AID - 10.1016/j.meatsci.2015.03.013 [doi]
PST - ppublish
SO  - Meat Sci. 2015 Jul;105:96-107. doi: 10.1016/j.meatsci.2015.03.013. Epub 2015 Mar 
      20.