PMID- 25828419
OWN - NLM
STAT- MEDLINE
DCOM- 20160401
LR  - 20220330
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 45
IP  - 6
DP  - 2015 Jun
TI  - Proton pump inhibitors utilisation in older people in New Zealand from 2005 to 
      2013.
PG  - 624-9
LID - 10.1111/imj.12757 [doi]
AB  - BACKGROUND: The prescriptions for proton pump inhibitors (PPI) to treat 
      acid-related disorders continue to rise internationally and in New Zealand. 
      Concerns have been raised regarding its widespread use, costs and potential 
      adverse effects in older people. AIMS: This study aimed to characterise the 
      utilisation of PPI by older people (aged 65 years and older) in New Zealand from 
      2005 to 2013. METHODS: Repeated cross-sectional analysis of population-level 
      dispensing data was conducted from 1 January 2005 to 31 December 2013. Dispensing 
      data for all PPI prescriptions from 2005 to 2013 were obtained from the Ministry 
      of Health, New Zealand. Utilisation was measured in defined daily doses (DDD) per 
      1000 older people per day using the World Health Organization Collaborating 
      Centre for Drug Statistics Methodology anatomic, therapeutic and chemical 
      classification system. Utilisation was standardised by sex, age, ethnicity and 
      district health board. RESULTS: Overall PPI utilisation showed a 26.7% increase 
      from 2005 to 2013, from 273.41 to 346.53 DDD/1000/day. The greatest utilisation 
      was observed in individuals aged between 80 and 84 years. Middle Eastern/Latin 
      American/African utilised more PPI compared with other ethnic groups. 
      CONCLUSIONS: Utilisation of PPI among older people in New Zealand increased by a 
      fifth from 2005 to 2013. Given the concerns surrounding the long-term PPI use in 
      older people, the appropriateness of the increased utilisation needs to be 
      continuously re-evaluated by prescribers and health policy makers.
CI  - (c) 2015 Royal Australasian College of Physicians.
FAU - Nishtala, P S
AU  - Nishtala PS
AD  - School of Pharmacy, University of Otago, Dunedin, New Zealand.
FAU - Soo, L
AU  - Soo L
AD  - School of Pharmacy, University of Otago, Dunedin, New Zealand.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Drug Utilization/*trends
MH  - Female
MH  - Humans
MH  - Male
MH  - New Zealand/epidemiology
MH  - Proton Pump Inhibitors/*therapeutic use
OTO - NOTNLM
OT  - defined daily dose
OT  - older person
OT  - omeprazole
OT  - proton pump inhibitor
OT  - utilisation
EDAT- 2015/04/02 06:00
MHDA- 2016/04/02 06:00
CRDT- 2015/04/02 06:00
PHST- 2014/08/06 00:00 [received]
PHST- 2015/03/07 00:00 [accepted]
PHST- 2015/04/02 06:00 [entrez]
PHST- 2015/04/02 06:00 [pubmed]
PHST- 2016/04/02 06:00 [medline]
AID - 10.1111/imj.12757 [doi]
PST - ppublish
SO  - Intern Med J. 2015 Jun;45(6):624-9. doi: 10.1111/imj.12757.