PMID- 25830624
OWN - NLM
STAT- MEDLINE
DCOM- 20160802
LR  - 20151022
IS  - 1532-4281 (Electronic)
IS  - 1079-9893 (Linking)
VI  - 35
IP  - 5
DP  - 2015
TI  - Effects of losartan on expression of monocyte chemoattractant protein-1 (MCP-1) 
      in hyperuricemic nephropathy rats.
PG  - 458-61
LID - 10.3109/10799893.2015.1006332 [doi]
AB  - The monocyte chemoattractant protein-1 (MCP-1) plays an important role in the 
      pathogenesis of progression of renal failure. This is based on the observations 
      done both in various animal models of renal damage and in different types of 
      human renal disease. During the development of non-infectious kidney stones, 
      crystals are formed and deposited on the kidneys and the kidneys are surrounded 
      by monocytes/macrophages. We have proposed that in response to crystal exposure, 
      renal epithelial cells produce chemokines, which attract the 
      monocytes/macrophages to the sites of crystal deposition. In this study, we 
      investigated the expression of MCP-1 protein by SD rats exposed to oxonic acid 
      (OA). Our study showed that hyperuricemia accelerates renal progression via a 
      mechanism linked to high MCP-1 which may mediate the inflammation reaction of 
      renal diseases induced by hyperuricemia. Losartan may retard the progression of 
      advanced renal dysfunction, and the mechanism was partly due to blocking of renal 
      inflammation induced by the uric acid. Because the number of experiments 
      performed here is very few, results must be confirmed by more extensive studies 
      with a larger sample size.
FAU - Yu, Shengyou
AU  - Yu S
AD  - a Guangzhou Medical University , Guangzhou , Guangdong Province , China .
AD  - b Guangzhou First People's Hospital , Guangzhou , Guangdong Province , China , 
      and.
FAU - Ren, Qi
AU  - Ren Q
AD  - c Guangzhou Women and Children's Medical Center, Sun Yat-Sen University , 
      Guangzhou , Guangdong Province , China.
FAU - Wu, Wei
AU  - Wu W
AD  - b Guangzhou First People's Hospital , Guangzhou , Guangdong Province , China , 
      and.
LA  - eng
PT  - Journal Article
DEP - 20150401
PL  - England
TA  - J Recept Signal Transduct Res
JT  - Journal of receptor and signal transduction research
JID - 9509432
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 268B43MJ25 (Uric Acid)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Hyperuricemia/complications/*drug therapy/*metabolism
MH  - Kidney/*metabolism
MH  - Kidney Diseases/drug therapy/etiology/*metabolism
MH  - Losartan/*administration & dosage
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Uric Acid/blood
OTO - NOTNLM
OT  - Hyperuricemic nephropathy
OT  - MCP-1
OT  - losartan
OT  - rat kidney
OT  - uric acid
EDAT- 2015/04/02 06:00
MHDA- 2016/08/03 06:00
CRDT- 2015/04/02 06:00
PHST- 2015/04/02 06:00 [entrez]
PHST- 2015/04/02 06:00 [pubmed]
PHST- 2016/08/03 06:00 [medline]
AID - 10.3109/10799893.2015.1006332 [doi]
PST - ppublish
SO  - J Recept Signal Transduct Res. 2015;35(5):458-61. doi: 
      10.3109/10799893.2015.1006332. Epub 2015 Apr 1.