PMID- 25832642
OWN - NLM
STAT- MEDLINE
DCOM- 20160112
LR  - 20220310
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 38
IP  - 4
DP  - 2015
TI  - Pseudokinase tribbles 1 (TRB1) negatively regulates tumor-suppressor activity of 
      p53 through p53 deacetylation.
PG  - 618-24
LID - 10.1248/bpb.b15-00003 [doi]
AB  - Tribbles 1 (TRB1) is one of the mammalian orthologs of Drosophila Tribbles, which 
      regulates development and cell proliferation. TRB1 is suggested to act as a 
      scaffold protein in signaling pathways for important cellular processes. TRB1 has 
      also been identified as a myeloid oncogenic driver and mediates leukemogenesis 
      through the mitogen-activated protein extracellular kinase (MEK)/extracellular 
      signal-regulated kinase (ERK) pathway and CCAAT/enhancer binding protein (C/EBP) 
      transcriptional factors. However, the physiological roles of TRB1 in solid tumors 
      have not been clarified. Here, we show that TRB1 interacts with p53 and 
      suppresses its tumor suppressor activity. TRB1 knockdown enhances transcriptional 
      activity of p53 and decreases cell viability. Interestingly, TRB1 enhances 
      histone deacety lase 1 (HDAC1)-mediated p53 deacetylation and decreases DNA 
      binding of p53. These results suggest that TRB1 is involved in the proliferation 
      of tumor cells by inhibiting the activities of tumor suppressor p53 in solid 
      tumors.
FAU - Miyajima, Chiharu
AU  - Miyajima C
AD  - Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical 
      Sciences, Nagoya City University.
FAU - Inoue, Yasumichi
AU  - Inoue Y
FAU - Hayashi, Hidetoshi
AU  - Hayashi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (CDKN1A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (TRIB1 protein, human)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 3.5.1.98 (HDAC1 protein, human)
RN  - EC 3.5.1.98 (Histone Deacetylase 1)
SB  - IM
MH  - Cell Line, Tumor
MH  - Cyclin-Dependent Kinase Inhibitor p21/genetics/metabolism
MH  - DNA/metabolism
MH  - Gene Knockdown Techniques
MH  - Histone Deacetylase 1/metabolism
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/genetics/*metabolism
MH  - Protein Serine-Threonine Kinases/*antagonists & inhibitors/genetics/metabolism
MH  - RNA, Small Interfering/genetics
MH  - Tumor Suppressor Protein p53/*metabolism
EDAT- 2015/04/04 06:00
MHDA- 2016/01/13 06:00
CRDT- 2015/04/03 06:00
PHST- 2015/04/03 06:00 [entrez]
PHST- 2015/04/04 06:00 [pubmed]
PHST- 2016/01/13 06:00 [medline]
AID - 10.1248/bpb.b15-00003 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2015;38(4):618-24. doi: 10.1248/bpb.b15-00003.