PMID- 25833101
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20181113
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 53
IP  - 5
DP  - 2016 Jul
TI  - Serum CXCL12 Levels as a Novel Predictor of Future Stroke Recurrence in Patients 
      with Acute Ischemic Stroke.
PG  - 2807-2814
LID - 10.1007/s12035-015-9151-0 [doi]
AB  - Previous studies had shown that CXC chemokine ligand-12 (CXCL12) plays a 
      significant role in animal models of ischemic stroke, but its role in human 
      stroke is unclear. The aim of this study was to test the relationship between 
      elevated serum circulating CXCL12 levels and the 1-year stroke recurrence in 
      Chinese patients with acute ischemic stroke (AIS). All consecutive patients with 
      first-ever acute ischemic stroke from January 2011 to September 2013 were 
      recruited to participate in the study. Serum levels of CXCL12 and National 
      Institute of Health Stroke Scale (NIHSS) were measured at the time of admission. 
      Logistic regression analysis was used to evaluate the stroke recurrence according 
      to serum CXCL12 levels. Receiver operating characteristic (ROC) curve was used to 
      evaluate the accuracy of serum CXCL12 in predicting stroke recurrence. Clinical 
      follow-up was performed at 1 year. In our study, 248 patients finished the 1-year 
      follow-up. At 1-year follow-up, 31 patients had a recurrence ischemic stroke. The 
      median CXCL12 levels were significantly higher in those who sustained a 
      recurrence ischemic stroke compared with those who did not [24.2 ng/mL (IQR 
      15.4-33.7) vs 6.5 ng/mL (IQR 3.4-10.2); Z = 8.258, P < 0.0001]. In multivariate 
      analysis, there was an increased risk of stroke recurrence associated with serum 
      CXCL12 levels >/=12.15 ng/mL (OR 9.122, 95 % CI 6.103-15.104) after adjusting for 
      above possible confounders. The time to recurrence stroke distribution between 
      patients with baseline CXCL12 levels >/=12.15 ng/mL and those with baseline CXCL12 
      levels <12.15 ng/mL were significantly different (P < 0.0001, log-rank test). 
      Elevated circulating CXCL12 levels at admission are strongly associated with the 
      future recurrence of ischemic stroke in Chinese patients with AIS. Further 
      studies are warranted to confirm this association and define the role for CXCL12 
      as a novel predictor biomarker for stroke recurrence.
FAU - Gu, Xiao-Lin
AU  - Gu XL
AD  - Department of Neurology, The People's Hospital of Laiwu City, No. 1, Xuehudajie, 
      Changshao North Road, Laiwu, 271100, Shandong Province, China. 
      neurokim011@126.com.
FAU - Liu, Lin
AU  - Liu L
AD  - Department of Neurology, The People's Hospital of Laiwu City, No. 1, Xuehudajie, 
      Changshao North Road, Laiwu, 271100, Shandong Province, China.
FAU - Lu, Xiang-Dong
AU  - Lu XD
AD  - Department of Neurosurgery, The People's Hospital of Laiwu City, Laiwu, 271100, 
      Shandong Province, China.
FAU - Liu, Zhen-Rui
AU  - Liu ZR
AD  - Department of Neurosurgery, The People's Hospital of Laiwu City, Laiwu, 271100, 
      Shandong Province, China.
LA  - eng
PT  - Journal Article
DEP - 20150402
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
SB  - IM
MH  - Aged
MH  - Brain Ischemia/*blood/*complications
MH  - Chemokine CXCL12/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - ROC Curve
MH  - Recurrence
MH  - Stroke/*blood/*complications
OTO - NOTNLM
OT  - Acute ischemic stroke
OT  - CXC chemokine ligand-12
OT  - Predictor
OT  - Recurrence
EDAT- 2015/04/03 06:00
MHDA- 2017/12/23 06:00
CRDT- 2015/04/03 06:00
PHST- 2015/01/29 00:00 [received]
PHST- 2015/03/19 00:00 [accepted]
PHST- 2015/04/03 06:00 [entrez]
PHST- 2015/04/03 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
AID - 10.1007/s12035-015-9151-0 [pii]
AID - 10.1007/s12035-015-9151-0 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2016 Jul;53(5):2807-2814. doi: 10.1007/s12035-015-9151-0. Epub 
      2015 Apr 2.